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Protecting group free radical C–H trifluoromethylation of peptides

Two radical-based approaches have been developed to effect the trifluoromethylation of aryl C–H bonds in native peptides either using stoichiometric oxidant or visible light photoredox catalysis. The reported methods are able to derivatize tyrosine and tryptophan sidechains under biocompatible condi...

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Detalles Bibliográficos
Autores principales:	Ichiishi, Naoko, Caldwell, John P., Lin, Melissa, Zhong, Wendy, Zhu, Xiaohong, Streckfuss, Eric, Kim, Hai-Young, Parish, Craig A., Krska, Shane W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941281/ https://www.ncbi.nlm.nih.gov/pubmed/29780547 http://dx.doi.org/10.1039/c8sc00368h

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