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Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications

RING (Really Interesting New Gene) domains in ubiquitin RING E3 ligases exclusively engage ubiquitin (Ub)-loaded E2s to facilitate ubiquitination of their substrates. Despite such specificity, all RINGs characterized till date bind unloaded E2s with dissociation constants (K(d)s) in the micromolar t...

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Detalles Bibliográficos
Autores principales:	Behera, Adaitya Prasad, Naskar, Pritam, Agarwal, Shubhangi, Banka, Prerana Agarwal, Poddar, Asim, Datta, Ajit B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941314/ https://www.ncbi.nlm.nih.gov/pubmed/29626159 http://dx.doi.org/10.1042/BCJ20170909

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