Thrombin and factor Xa link the coagulation system with liver fibrosis

BACKGROUND: Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated. We aimed to evaluate the impact of FXa and thrombin in vitro on stellate cells and their respective inhibition in vivo using a rodent mode...

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Detalles Bibliográficos
Autores principales: Dhar, Ameet, Sadiq, Fouzia, Anstee, Quentin M., Levene, Adam P., Goldin, Robert D., Thursz, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941658/
https://www.ncbi.nlm.nih.gov/pubmed/29739329
http://dx.doi.org/10.1186/s12876-018-0789-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941658/
https://www.ncbi.nlm.nih.gov/pubmed/29739329
http://dx.doi.org/10.1186/s12876-018-0789-8

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