Cargando…

Thrombin and factor Xa link the coagulation system with liver fibrosis

BACKGROUND: Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated. We aimed to evaluate the impact of FXa and thrombin in vitro on stellate cells and their respective inhibition in vivo using a rodent mode...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dhar, Ameet, Sadiq, Fouzia, Anstee, Quentin M., Levene, Adam P., Goldin, Robert D., Thursz, Mark R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941658/ https://www.ncbi.nlm.nih.gov/pubmed/29739329 http://dx.doi.org/10.1186/s12876-018-0789-8

Ejemplares similares

Coagulation Factor Xa
por: Brown, Mark A., et al.
Publicado: (2013)

Liver function tests and metabolic-associated fatty liver disease: Changes in upper normal limits, does it really matter?
por: Forlano, Roberta, et al.
Publicado: (2021)

Parallel imaging of coagulation pathway proteases activated protein C, thrombin, and factor Xa in human plasma
por: Modrzycka, Sylwia, et al.
Publicado: (2022)

Functional assembly of intrinsic coagulation proteases on monocytes and platelets. Comparison between cofactor activities induced by thrombin and factor Xa
Publicado: (1992)

Roles of factor Xa beyond coagulation
por: Ruf, Wolfram
Publicado: (2021)

The coagulation factor Xa/protease activated receptor-2 axis in the progression of liver fibrosis: a multifaceted paradigm
por: Borensztajn, Keren, et al.
Publicado: (2010)

The Tick-Derived Anticoagulant Madanin Is Processed by Thrombin and Factor Xa
por: Figueiredo, Ana C., et al.
Publicado: (2013)

Procoagulant activity of human tumours: existence of Xa and thrombin-like activities.
por: Sarode, R., et al.
Publicado: (1990)

Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver
por: Rashid, S. Tamir, et al.
Publicado: (2012)

Spatial Distribution of Factor Xa, Thrombin, and Fibrin(ogen) on Thrombi at Venous Shear
por: Berny, Michelle A., et al.
Publicado: (2010)

Factor Xa Generation by Computational Modeling: An Additional Discriminator to Thrombin Generation Evaluation
por: Brummel-Ziedins, Kathleen E., et al.
Publicado: (2012)

Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex
por: Yegneswaran, Subramanian, et al.
Publicado: (2015)

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin
por: Burzynski, Laura C., et al.
Publicado: (2019)

Factor Xa inhibition by rivaroxaban in the trough steady state can significantly reduce thrombin generation
por: Horinaka, Shigeo, et al.
Publicado: (2017)

Thrombin generation: a global coagulation procedure to investigate hypo- and hyper-coagulability
por: Tripodi, Armando
Publicado: (2020)

Coagulation, Microenvironment and Liver Fibrosis
por: Bitto, Niccolò, et al.
Publicado: (2018)

Comparison of antithrombin‐dependent and direct inhibitors of factor Xa or thrombin on the kinetics and qualitative characteristics of blood clots
por: Salta, Stella, et al.
Publicado: (2018)

Andexanet versus prothrombin complex concentrates: Differences in reversal of factor Xa inhibitors in in vitro thrombin generation
por: Lu, Genmin, et al.
Publicado: (2020)

Thrombin and Factor Xa Hydrolysis of Chromogenic Substrates in the Presence of Sulfated Derivatives of Galactomannan and Galactoglucomannan Natural Gels
por: Drozd, Natalia N., et al.
Publicado: (2022)

Deciphering the coagulation profile through the dynamics of thrombin activity
por: de Laat-Kremers, Romy M. W., et al.
Publicado: (2020)

Characterization of thrombin/factor Xa inhibitors in Rhizoma Chuanxiong through UPLC-MS-based multivariate statistical analysis
por: Yang, Yi-Yao, et al.
Publicado: (2020)

Reversing direct factor Xa or thrombin inhibitors: Factor V addition to prothrombin complex concentrate is beneficial in vitro
por: Brinkman, Herm Jan M., et al.
Publicado: (2022)

Metabolic Profile Reflects Stages of Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease
por: Jambulingam, Nila, et al.
Publicado: (2023)

Anti-factor Xa antibodies in patients with antiphospholipid syndrome and their effects upon coagulation assays
por: Artim-Esen, Bahar, et al.
Publicado: (2015)

Antiplatelet Aggregation Properties of Cirsilineol: A Novel Inhibitor of Blood Coagulation Factor Xa
por: Kim, Go Oun, et al.
Publicado: (2023)

Intrinsic coagulation pathway-mediated thrombin generation in mouse whole blood
por: Konrath, Sandra, et al.
Publicado: (2022)

STUDIES ON BLOOD COAGULATION : III. ON THE CONSTANCY OF THE HYDROGEN ION CONCENTRATION DURING THE COAGULATION OF FIBRINOGEN BY THROMBIN
por: Eagle, Harry, et al.
Publicado: (1935)

The Role of Liver Fibrosis Assessment in the Management of Patients with Chronic Hepatitis B Infection: Lessons Learned from a Single Centre Experience
por: Malik, Raza, et al.
Publicado: (2011)

Direct thrombin inhibitors, but not the direct factor Xa inhibitor rivaroxaban, increase tissue factor-induced hypercoagulability in vitro and in vivo
por: Perzborn, E, et al.
Publicado: (2014)

Thermodynamics of Water in an Enzyme Active Site: Grid-Based Hydration Analysis of Coagulation Factor Xa
por: Nguyen, Crystal N., et al.
Publicado: (2014)

Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice
por: Posthuma, Jelle J., et al.
Publicado: (2019)

Differential Assessment of Factor Xa Activity and Global Blood Coagulability Utilizing Novel Dielectric Coagulometry
por: Hamada, Satomi, et al.
Publicado: (2018)

Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation
por: Arce, Maximiliano, et al.
Publicado: (2019)

Molecular Dynamics Simulation Study of the Selective Inhibition of Coagulation Factor IXa over Factor Xa
por: Yoon, Hyun Jung, et al.
Publicado: (2023)

STUDIES ON BLOOD COAGULATION : II. THE FORMATION OF FIBRIN FROM THROMBIN AND FIBRINOGEN
por: Eagle, Harry
Publicado: (1935)

STUDIES ON BLOOD COAGULATION : I. THE RÔLE OF PROTHROMBIN AND OF PLATELETS IN THE FORMATION OF THROMBIN
por: Eagle, Harry
Publicado: (1935)

Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond
por: Danckwardt, Sven, et al.
Publicado: (2013)

Coagulation Factor XII Levels and Intrinsic Thrombin Generation in Multiple Sclerosis
por: Ziliotto, Nicole, et al.
Publicado: (2018)

Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies
por: Slatter, David A., et al.
Publicado: (2018)

Hemostasis, coagulation and thrombin in venoarterial and venovenous extracorporeal membrane oxygenation: the HECTIC study
por: Cartwright, Bruce, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3e9j9r5au0gdss4f5ug0mu6ojv