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Gender difference in the effects of interleukin-6 on grip strength – a systematic review and meta-analysis

BACKGROUND: Aging sarcopenia characterized by low muscle mass with low muscle strength affects men and women differently. The contribution of interleukin-6 (IL-6) to sarcopenia has been suggested based on a negative correlation between plasma IL-6 and muscle function described by some studies. Howev...

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Autores principales: Mikó, Alexandra, Pótó, László, Mátrai, Péter, Hegyi, Péter, Füredi, Nóra, Garami, András, Illés, Anita, Solymár, Margit, Vincze, Áron, Balaskó, Márta, Pár, Gabriella, Sarlós, Patrícia, Bajor, Judit, Tenk, Judit, Rostás, Ildikó, Pétervári, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941705/
https://www.ncbi.nlm.nih.gov/pubmed/29739343
http://dx.doi.org/10.1186/s12877-018-0798-z
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author Mikó, Alexandra
Pótó, László
Mátrai, Péter
Hegyi, Péter
Füredi, Nóra
Garami, András
Illés, Anita
Solymár, Margit
Vincze, Áron
Balaskó, Márta
Pár, Gabriella
Sarlós, Patrícia
Bajor, Judit
Tenk, Judit
Rostás, Ildikó
Pétervári, Erika
author_facet Mikó, Alexandra
Pótó, László
Mátrai, Péter
Hegyi, Péter
Füredi, Nóra
Garami, András
Illés, Anita
Solymár, Margit
Vincze, Áron
Balaskó, Márta
Pár, Gabriella
Sarlós, Patrícia
Bajor, Judit
Tenk, Judit
Rostás, Ildikó
Pétervári, Erika
author_sort Mikó, Alexandra
collection PubMed
description BACKGROUND: Aging sarcopenia characterized by low muscle mass with low muscle strength affects men and women differently. The contribution of interleukin-6 (IL-6) to sarcopenia has been suggested based on a negative correlation between plasma IL-6 and muscle function described by some studies. However, no consensus regarding clinically relevant cut-off criteria has been reached. Another question arises whether pooling male and female data is an accurate way to determine the predictive value of IL-6 in sarcopenia. The present meta-analysis was designed to assess: (1) whether plasma IL-6 in aged populations in fact correlates negatively to muscle strength; (2) whether such a correlation exists both in men and in women; and (3) whether plasma IL-6 shows a gender difference in old age. METHODS: We applied the preferred reporting items for systematic review and meta-analysis protocols (PRISMA). We searched PubMed and Embase for papers that reported data on individuals over 65 without inflammatory diseases. We extracted either separate male and female data on plasma IL-6 along with at least one muscle parameter or correlation coefficient between plasma IL-6 and these parameters. Random effect models calculated with DerSimonian and Laird weighting methods were applied to analyze correlation coefficients and gender difference in plasma IL-6. Egger’s test was used to assess the small study effect. RESULTS: Twenty articles out of 468 records identified were suitable for analyses. Plasma IL-6 correlates negatively with grip strength in mixed populations and also separately in men [− 0.25 with 95% confidence interval (CI): − 0.48, − 0.02] and in women (− 0.14 with 95% CI: − 0.24, − 0.03). However, contrary to expectations, men with better muscle condition have higher plasma IL-6 than women of similar age with worse muscle condition (plasma IL-6 male–female difference: 0.25 pg/mL with 95% CI: 0.15, 0.35). CONCLUSION: This is the first study to demonstrate that a higher predictive IL-6 cut-off level should be determined for aging sarcopenia in men than in women. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12877-018-0798-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-59417052018-05-14 Gender difference in the effects of interleukin-6 on grip strength – a systematic review and meta-analysis Mikó, Alexandra Pótó, László Mátrai, Péter Hegyi, Péter Füredi, Nóra Garami, András Illés, Anita Solymár, Margit Vincze, Áron Balaskó, Márta Pár, Gabriella Sarlós, Patrícia Bajor, Judit Tenk, Judit Rostás, Ildikó Pétervári, Erika BMC Geriatr Research Article BACKGROUND: Aging sarcopenia characterized by low muscle mass with low muscle strength affects men and women differently. The contribution of interleukin-6 (IL-6) to sarcopenia has been suggested based on a negative correlation between plasma IL-6 and muscle function described by some studies. However, no consensus regarding clinically relevant cut-off criteria has been reached. Another question arises whether pooling male and female data is an accurate way to determine the predictive value of IL-6 in sarcopenia. The present meta-analysis was designed to assess: (1) whether plasma IL-6 in aged populations in fact correlates negatively to muscle strength; (2) whether such a correlation exists both in men and in women; and (3) whether plasma IL-6 shows a gender difference in old age. METHODS: We applied the preferred reporting items for systematic review and meta-analysis protocols (PRISMA). We searched PubMed and Embase for papers that reported data on individuals over 65 without inflammatory diseases. We extracted either separate male and female data on plasma IL-6 along with at least one muscle parameter or correlation coefficient between plasma IL-6 and these parameters. Random effect models calculated with DerSimonian and Laird weighting methods were applied to analyze correlation coefficients and gender difference in plasma IL-6. Egger’s test was used to assess the small study effect. RESULTS: Twenty articles out of 468 records identified were suitable for analyses. Plasma IL-6 correlates negatively with grip strength in mixed populations and also separately in men [− 0.25 with 95% confidence interval (CI): − 0.48, − 0.02] and in women (− 0.14 with 95% CI: − 0.24, − 0.03). However, contrary to expectations, men with better muscle condition have higher plasma IL-6 than women of similar age with worse muscle condition (plasma IL-6 male–female difference: 0.25 pg/mL with 95% CI: 0.15, 0.35). CONCLUSION: This is the first study to demonstrate that a higher predictive IL-6 cut-off level should be determined for aging sarcopenia in men than in women. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12877-018-0798-z) contains supplementary material, which is available to authorized users. BioMed Central 2018-05-08 /pmc/articles/PMC5941705/ /pubmed/29739343 http://dx.doi.org/10.1186/s12877-018-0798-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Mikó, Alexandra
Pótó, László
Mátrai, Péter
Hegyi, Péter
Füredi, Nóra
Garami, András
Illés, Anita
Solymár, Margit
Vincze, Áron
Balaskó, Márta
Pár, Gabriella
Sarlós, Patrícia
Bajor, Judit
Tenk, Judit
Rostás, Ildikó
Pétervári, Erika
Gender difference in the effects of interleukin-6 on grip strength – a systematic review and meta-analysis
title Gender difference in the effects of interleukin-6 on grip strength – a systematic review and meta-analysis
title_full Gender difference in the effects of interleukin-6 on grip strength – a systematic review and meta-analysis
title_fullStr Gender difference in the effects of interleukin-6 on grip strength – a systematic review and meta-analysis
title_full_unstemmed Gender difference in the effects of interleukin-6 on grip strength – a systematic review and meta-analysis
title_short Gender difference in the effects of interleukin-6 on grip strength – a systematic review and meta-analysis
title_sort gender difference in the effects of interleukin-6 on grip strength – a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941705/
https://www.ncbi.nlm.nih.gov/pubmed/29739343
http://dx.doi.org/10.1186/s12877-018-0798-z
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