Cutaneous Basal Cell Carcinoma with Lymph Node and Pulmonary Metastases

Basal cell carcinoma (BCC) is the most common skin cancer. Metastatic BCC is an extraordinary rare finding observed in only 0.5% of all cases. Until the introduction of the small molecule hedgehog inhibitor vismodegib, patients with metastatic BCC were treated with chemotherapy, most frequently plat...

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Detalles Bibliográficos
Autores principales: Wahl, Renate U., Cacchi, Claudio, Rübben, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941720/
https://www.ncbi.nlm.nih.gov/pubmed/29854516
http://dx.doi.org/10.1155/2018/3485326
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author Wahl, Renate U.
Cacchi, Claudio
Rübben, Albert
author_facet Wahl, Renate U.
Cacchi, Claudio
Rübben, Albert
author_sort Wahl, Renate U.
collection PubMed
description Basal cell carcinoma (BCC) is the most common skin cancer. Metastatic BCC is an extraordinary rare finding observed in only 0.5% of all cases. Until the introduction of the small molecule hedgehog inhibitor vismodegib, patients with metastatic BCC were treated with chemotherapy, most frequently platinum-based with mixed responses to therapy. We present the case of a 55-year-old Caucasian man who suffered from BCC on his left arm with lymph node and pulmonary metastases. Sonic hedgehog blockade with vismodegib only induced a short remission, and the patient succumbed to the cancer.
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spelling pubmed-59417202018-05-31 Cutaneous Basal Cell Carcinoma with Lymph Node and Pulmonary Metastases Wahl, Renate U. Cacchi, Claudio Rübben, Albert Case Rep Oncol Med Case Report Basal cell carcinoma (BCC) is the most common skin cancer. Metastatic BCC is an extraordinary rare finding observed in only 0.5% of all cases. Until the introduction of the small molecule hedgehog inhibitor vismodegib, patients with metastatic BCC were treated with chemotherapy, most frequently platinum-based with mixed responses to therapy. We present the case of a 55-year-old Caucasian man who suffered from BCC on his left arm with lymph node and pulmonary metastases. Sonic hedgehog blockade with vismodegib only induced a short remission, and the patient succumbed to the cancer. Hindawi 2018-04-24 /pmc/articles/PMC5941720/ /pubmed/29854516 http://dx.doi.org/10.1155/2018/3485326 Text en Copyright © 2018 Renate U. Wahl et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Wahl, Renate U.
Cacchi, Claudio
Rübben, Albert
Cutaneous Basal Cell Carcinoma with Lymph Node and Pulmonary Metastases
title Cutaneous Basal Cell Carcinoma with Lymph Node and Pulmonary Metastases
title_full Cutaneous Basal Cell Carcinoma with Lymph Node and Pulmonary Metastases
title_fullStr Cutaneous Basal Cell Carcinoma with Lymph Node and Pulmonary Metastases
title_full_unstemmed Cutaneous Basal Cell Carcinoma with Lymph Node and Pulmonary Metastases
title_short Cutaneous Basal Cell Carcinoma with Lymph Node and Pulmonary Metastases
title_sort cutaneous basal cell carcinoma with lymph node and pulmonary metastases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941720/
https://www.ncbi.nlm.nih.gov/pubmed/29854516
http://dx.doi.org/10.1155/2018/3485326
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