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A Systematic Review of the Causes and Management of Nonthrombotic Embolic Stroke of Tissue Origin
INTRODUCTION: Various bodily tissues have been reported to enter the arterial circulation and embolize to the brain resulting in ischemic stroke. Most frequently nonthrombotic embolic stroke (NTES) of tissue origin is iatrogenic or related to an underlying disease process. With the increase in elect...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941808/ https://www.ncbi.nlm.nih.gov/pubmed/29854382 http://dx.doi.org/10.1155/2018/8092862 |
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author | Mello, Sarah Judge, Ciaran Kelly, Roisin Bradley, David Harbison, Joseph |
author_facet | Mello, Sarah Judge, Ciaran Kelly, Roisin Bradley, David Harbison, Joseph |
author_sort | Mello, Sarah |
collection | PubMed |
description | INTRODUCTION: Various bodily tissues have been reported to enter the arterial circulation and embolize to the brain resulting in ischemic stroke. Most frequently nonthrombotic embolic stroke (NTES) of tissue origin is iatrogenic or related to an underlying disease process. With the increase in elective surgery and intravascular procedures, NTES may increase in prevalence. AIM: To compile a summary of the background, incidence, presentation, and treatment of NTES of tissue origin, by conducting a systematic review of the current literature. SUMMARY OF REVIEW: We searched EMBASE and MEDLINE for articles on NTES of tissue origin published in English with no restriction on publication date (search date June 2017). 800 articles were identified and screened and 159 articles were ultimately reviewed in full text and included in qualitative analysis. Articles deemed relevant were assessed by a second reviewer to confirm compatibility with the inclusion criteria. References of included articles were reviewed for relevant publications. We categorized the pathology of the emboli into the following groups: amniotic fluid (4 publications), tumour (60 publications), fat (43 publications), cholesterol (19 publications), and intravascular debris (12 publications). We then summarized the available literature on each cause of NTES. CONCLUSIONS: NTES of tissue origin is an uncommon but important diagnosis to consider particularly in younger stroke patients and in certain clinical settings. Treatment for NTES is currently anecdotal and based on small case series. Embolectomy may emerge as the therapy of choice due to the longer treatment timeframe and heterogeneity of the emboli. |
format | Online Article Text |
id | pubmed-5941808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-59418082018-05-31 A Systematic Review of the Causes and Management of Nonthrombotic Embolic Stroke of Tissue Origin Mello, Sarah Judge, Ciaran Kelly, Roisin Bradley, David Harbison, Joseph Stroke Res Treat Review Article INTRODUCTION: Various bodily tissues have been reported to enter the arterial circulation and embolize to the brain resulting in ischemic stroke. Most frequently nonthrombotic embolic stroke (NTES) of tissue origin is iatrogenic or related to an underlying disease process. With the increase in elective surgery and intravascular procedures, NTES may increase in prevalence. AIM: To compile a summary of the background, incidence, presentation, and treatment of NTES of tissue origin, by conducting a systematic review of the current literature. SUMMARY OF REVIEW: We searched EMBASE and MEDLINE for articles on NTES of tissue origin published in English with no restriction on publication date (search date June 2017). 800 articles were identified and screened and 159 articles were ultimately reviewed in full text and included in qualitative analysis. Articles deemed relevant were assessed by a second reviewer to confirm compatibility with the inclusion criteria. References of included articles were reviewed for relevant publications. We categorized the pathology of the emboli into the following groups: amniotic fluid (4 publications), tumour (60 publications), fat (43 publications), cholesterol (19 publications), and intravascular debris (12 publications). We then summarized the available literature on each cause of NTES. CONCLUSIONS: NTES of tissue origin is an uncommon but important diagnosis to consider particularly in younger stroke patients and in certain clinical settings. Treatment for NTES is currently anecdotal and based on small case series. Embolectomy may emerge as the therapy of choice due to the longer treatment timeframe and heterogeneity of the emboli. Hindawi 2018-04-24 /pmc/articles/PMC5941808/ /pubmed/29854382 http://dx.doi.org/10.1155/2018/8092862 Text en Copyright © 2018 Sarah Mello et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Mello, Sarah Judge, Ciaran Kelly, Roisin Bradley, David Harbison, Joseph A Systematic Review of the Causes and Management of Nonthrombotic Embolic Stroke of Tissue Origin |
title | A Systematic Review of the Causes and Management of Nonthrombotic Embolic Stroke of Tissue Origin |
title_full | A Systematic Review of the Causes and Management of Nonthrombotic Embolic Stroke of Tissue Origin |
title_fullStr | A Systematic Review of the Causes and Management of Nonthrombotic Embolic Stroke of Tissue Origin |
title_full_unstemmed | A Systematic Review of the Causes and Management of Nonthrombotic Embolic Stroke of Tissue Origin |
title_short | A Systematic Review of the Causes and Management of Nonthrombotic Embolic Stroke of Tissue Origin |
title_sort | systematic review of the causes and management of nonthrombotic embolic stroke of tissue origin |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941808/ https://www.ncbi.nlm.nih.gov/pubmed/29854382 http://dx.doi.org/10.1155/2018/8092862 |
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