Effects of mid-respiratory chain inhibition on mitochondrial function in vitro and in vivo

Relating the in vitro mitochondrial effects of drug candidates to likely in vivo outcomes remains challenging. Better understanding of this relationship, alongside improved methods to assess mitochondrial dysfunction in vivo, would both guide safer drug candidate selection and better support discove...

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Detalles Bibliográficos
Autores principales: Broom, Ashley J., Ambroso, Jeffrey, Brunori, Gino, Burns, Angie K., Armitage, James R., Francis, Ian, Gandhi, Mitul, Peterson, Richard A., Gant, Timothy W., Boobis, Alan R., Lyon, Jonathan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941817/
https://www.ncbi.nlm.nih.gov/pubmed/29780577
http://dx.doi.org/10.1039/c5tx00197h

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