Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties

High-mobility group A (HMGA) proteins have been examined to understand their participation as structural epigenetic chromatin factors that confer stem-like properties to embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and cancer stem cells (CSCs). The function of HMGA was evalua...

Descripción completa

Detalles Bibliográficos
Autores principales: Giancotti, Vincenzo, Bergamin, Natascha, Cataldi, Palmina, Rizzi, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941823/
https://www.ncbi.nlm.nih.gov/pubmed/29853899
http://dx.doi.org/10.1155/2018/3698078
_version_ 1783321364176830464
author Giancotti, Vincenzo
Bergamin, Natascha
Cataldi, Palmina
Rizzi, Claudio
author_facet Giancotti, Vincenzo
Bergamin, Natascha
Cataldi, Palmina
Rizzi, Claudio
author_sort Giancotti, Vincenzo
collection PubMed
description High-mobility group A (HMGA) proteins have been examined to understand their participation as structural epigenetic chromatin factors that confer stem-like properties to embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and cancer stem cells (CSCs). The function of HMGA was evaluated in conjunction with that of other epigenetic factors such as histones and microRNAs (miRs), taking into consideration the posttranscriptional modifications (PTMs) of histones (acetylation and methylation) and DNA methylation. HMGA proteins were coordinated or associated with histone and DNA modification and the expression of the factors related to pluripotency. CSCs showed remarkable differences compared with ESCs and iPSCs.
format Online
Article
Text
id pubmed-5941823
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-59418232018-05-31 Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties Giancotti, Vincenzo Bergamin, Natascha Cataldi, Palmina Rizzi, Claudio Int J Cell Biol Review Article High-mobility group A (HMGA) proteins have been examined to understand their participation as structural epigenetic chromatin factors that confer stem-like properties to embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and cancer stem cells (CSCs). The function of HMGA was evaluated in conjunction with that of other epigenetic factors such as histones and microRNAs (miRs), taking into consideration the posttranscriptional modifications (PTMs) of histones (acetylation and methylation) and DNA methylation. HMGA proteins were coordinated or associated with histone and DNA modification and the expression of the factors related to pluripotency. CSCs showed remarkable differences compared with ESCs and iPSCs. Hindawi 2018-04-24 /pmc/articles/PMC5941823/ /pubmed/29853899 http://dx.doi.org/10.1155/2018/3698078 Text en Copyright © 2018 Vincenzo Giancotti et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Giancotti, Vincenzo
Bergamin, Natascha
Cataldi, Palmina
Rizzi, Claudio
Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties
title Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties
title_full Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties
title_fullStr Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties
title_full_unstemmed Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties
title_short Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties
title_sort epigenetic contribution of high-mobility group a proteins to stem cell properties
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941823/
https://www.ncbi.nlm.nih.gov/pubmed/29853899
http://dx.doi.org/10.1155/2018/3698078
work_keys_str_mv AT giancottivincenzo epigeneticcontributionofhighmobilitygroupaproteinstostemcellproperties
AT bergaminnatascha epigeneticcontributionofhighmobilitygroupaproteinstostemcellproperties
AT cataldipalmina epigeneticcontributionofhighmobilitygroupaproteinstostemcellproperties
AT rizziclaudio epigeneticcontributionofhighmobilitygroupaproteinstostemcellproperties

Ejemplares similares