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A review of therapeutic agents for the management of pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is an uncommon, progressive and life threatening disease characterized by a proliferative vasculopathy of the small muscular pulmonary arterioles resulting in elevated pulmonary vascular resistance and eventually right ventricular failure. An increasing understa...

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Detalles Bibliográficos
Autores principales: Hahn, Stella S, Makaryus, Mina, Talwar, Arunabh, Narasimhan, Mangala, Zaidi, Gulrukh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941973/
https://www.ncbi.nlm.nih.gov/pubmed/27595643
http://dx.doi.org/10.1177/1753465816665289
Descripción
Sumario:Pulmonary arterial hypertension (PAH) is an uncommon, progressive and life threatening disease characterized by a proliferative vasculopathy of the small muscular pulmonary arterioles resulting in elevated pulmonary vascular resistance and eventually right ventricular failure. An increasing understanding of the pathobiology of PAH and its natural history has led to the development of numerous targeted therapies. Despite these advances there is significant progression of disease and the survival rate remains low. This article reviews the agents currently available for the medical management of PAH.