A review of therapeutic agents for the management of pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is an uncommon, progressive and life threatening disease characterized by a proliferative vasculopathy of the small muscular pulmonary arterioles resulting in elevated pulmonary vascular resistance and eventually right ventricular failure. An increasing understa...

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Detalles Bibliográficos
Autores principales: Hahn, Stella S, Makaryus, Mina, Talwar, Arunabh, Narasimhan, Mangala, Zaidi, Gulrukh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941973/
https://www.ncbi.nlm.nih.gov/pubmed/27595643
http://dx.doi.org/10.1177/1753465816665289
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author Hahn, Stella S
Makaryus, Mina
Talwar, Arunabh
Narasimhan, Mangala
Zaidi, Gulrukh
author_facet Hahn, Stella S
Makaryus, Mina
Talwar, Arunabh
Narasimhan, Mangala
Zaidi, Gulrukh
author_sort Hahn, Stella S
collection PubMed
description Pulmonary arterial hypertension (PAH) is an uncommon, progressive and life threatening disease characterized by a proliferative vasculopathy of the small muscular pulmonary arterioles resulting in elevated pulmonary vascular resistance and eventually right ventricular failure. An increasing understanding of the pathobiology of PAH and its natural history has led to the development of numerous targeted therapies. Despite these advances there is significant progression of disease and the survival rate remains low. This article reviews the agents currently available for the medical management of PAH.
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spelling pubmed-59419732018-05-09 A review of therapeutic agents for the management of pulmonary arterial hypertension Hahn, Stella S Makaryus, Mina Talwar, Arunabh Narasimhan, Mangala Zaidi, Gulrukh Ther Adv Respir Dis Reviews Pulmonary arterial hypertension (PAH) is an uncommon, progressive and life threatening disease characterized by a proliferative vasculopathy of the small muscular pulmonary arterioles resulting in elevated pulmonary vascular resistance and eventually right ventricular failure. An increasing understanding of the pathobiology of PAH and its natural history has led to the development of numerous targeted therapies. Despite these advances there is significant progression of disease and the survival rate remains low. This article reviews the agents currently available for the medical management of PAH. SAGE Publications 2016-09-05 2017-01 /pmc/articles/PMC5941973/ /pubmed/27595643 http://dx.doi.org/10.1177/1753465816665289 Text en © The Author(s), 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Reviews
Hahn, Stella S
Makaryus, Mina
Talwar, Arunabh
Narasimhan, Mangala
Zaidi, Gulrukh
A review of therapeutic agents for the management of pulmonary arterial hypertension
title A review of therapeutic agents for the management of pulmonary arterial hypertension
title_full A review of therapeutic agents for the management of pulmonary arterial hypertension
title_fullStr A review of therapeutic agents for the management of pulmonary arterial hypertension
title_full_unstemmed A review of therapeutic agents for the management of pulmonary arterial hypertension
title_short A review of therapeutic agents for the management of pulmonary arterial hypertension
title_sort review of therapeutic agents for the management of pulmonary arterial hypertension
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941973/
https://www.ncbi.nlm.nih.gov/pubmed/27595643
http://dx.doi.org/10.1177/1753465816665289
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