Synchronous Presence of EGFR, ALK Driver Mutations Along With PD L1 Overexpression in a Resected Early Stage Non-Small Cell Lung Cancer: A Case Report and Review of Literature

Treatment of lung cancer has been revolutionized with development of drugs that target key driver mutations and immune checkpoints. Until recently, it was believed that these driver mutations are mutually exclusive. However, few reports have emerged citing the presence of both mutations either synch...

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Autores principales: Thumallapally, Nishitha, Parylo, Sara, Vennepureddy, Adarsh, Ibrahim, Uroosa, Sokoloff, Alisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942208/
https://www.ncbi.nlm.nih.gov/pubmed/29760833
http://dx.doi.org/10.14740/wjon1090e
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author Thumallapally, Nishitha
Parylo, Sara
Vennepureddy, Adarsh
Ibrahim, Uroosa
Sokoloff, Alisa
author_facet Thumallapally, Nishitha
Parylo, Sara
Vennepureddy, Adarsh
Ibrahim, Uroosa
Sokoloff, Alisa
author_sort Thumallapally, Nishitha
collection PubMed
description Treatment of lung cancer has been revolutionized with development of drugs that target key driver mutations and immune checkpoints. Until recently, it was believed that these driver mutations are mutually exclusive. However, few reports have emerged citing the presence of both mutations either synchronously or metachronously. We describe a case report of lung adenocarcinoma harboring two driver mutations in the same tumor cells as well as exhibiting high PDL1 expression. We further discuss the possible association of these driver mutations with PDL1 expression.
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spelling pubmed-59422082018-05-14 Synchronous Presence of EGFR, ALK Driver Mutations Along With PD L1 Overexpression in a Resected Early Stage Non-Small Cell Lung Cancer: A Case Report and Review of Literature Thumallapally, Nishitha Parylo, Sara Vennepureddy, Adarsh Ibrahim, Uroosa Sokoloff, Alisa World J Oncol Case Report Treatment of lung cancer has been revolutionized with development of drugs that target key driver mutations and immune checkpoints. Until recently, it was believed that these driver mutations are mutually exclusive. However, few reports have emerged citing the presence of both mutations either synchronously or metachronously. We describe a case report of lung adenocarcinoma harboring two driver mutations in the same tumor cells as well as exhibiting high PDL1 expression. We further discuss the possible association of these driver mutations with PDL1 expression. Elmer Press 2018-04 2018-05-01 /pmc/articles/PMC5942208/ /pubmed/29760833 http://dx.doi.org/10.14740/wjon1090e Text en Copyright 2018, Thumallapally et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Thumallapally, Nishitha
Parylo, Sara
Vennepureddy, Adarsh
Ibrahim, Uroosa
Sokoloff, Alisa
Synchronous Presence of EGFR, ALK Driver Mutations Along With PD L1 Overexpression in a Resected Early Stage Non-Small Cell Lung Cancer: A Case Report and Review of Literature
title Synchronous Presence of EGFR, ALK Driver Mutations Along With PD L1 Overexpression in a Resected Early Stage Non-Small Cell Lung Cancer: A Case Report and Review of Literature
title_full Synchronous Presence of EGFR, ALK Driver Mutations Along With PD L1 Overexpression in a Resected Early Stage Non-Small Cell Lung Cancer: A Case Report and Review of Literature
title_fullStr Synchronous Presence of EGFR, ALK Driver Mutations Along With PD L1 Overexpression in a Resected Early Stage Non-Small Cell Lung Cancer: A Case Report and Review of Literature
title_full_unstemmed Synchronous Presence of EGFR, ALK Driver Mutations Along With PD L1 Overexpression in a Resected Early Stage Non-Small Cell Lung Cancer: A Case Report and Review of Literature
title_short Synchronous Presence of EGFR, ALK Driver Mutations Along With PD L1 Overexpression in a Resected Early Stage Non-Small Cell Lung Cancer: A Case Report and Review of Literature
title_sort synchronous presence of egfr, alk driver mutations along with pd l1 overexpression in a resected early stage non-small cell lung cancer: a case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942208/
https://www.ncbi.nlm.nih.gov/pubmed/29760833
http://dx.doi.org/10.14740/wjon1090e
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