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Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study

INTRODUCTION: The prevalence of postnatal depression (PND) is significant: reaching up to 20% in the general population. In mechanistic terms, the risk of PND lies in an interaction between a maternal psychophysiological vulnerability and a chronic environmental context of stress. On the one hand, r...

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Autores principales: Tharwat, Dahlia, Trousselard, Marion, Balès, Mélanie, Sutter-Dallay, Anne-Laure, Fromage, Dominique, Spitz, Elisabeth, Dallay, Dominique, Harvey, Thierry, Welter, Eric, Coatleven, Frédéric, Cherier, Lydie, Teissèdre, Frédérique, Pouly, Jean-Luc, Dutheil, Frédéric, Duffaud, Anaïs M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942420/
https://www.ncbi.nlm.nih.gov/pubmed/29724735
http://dx.doi.org/10.1136/bmjopen-2017-018317
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author Tharwat, Dahlia
Trousselard, Marion
Balès, Mélanie
Sutter-Dallay, Anne-Laure
Fromage, Dominique
Spitz, Elisabeth
Dallay, Dominique
Harvey, Thierry
Welter, Eric
Coatleven, Frédéric
Cherier, Lydie
Teissèdre, Frédérique
Pouly, Jean-Luc
Dutheil, Frédéric
Duffaud, Anaïs M
author_facet Tharwat, Dahlia
Trousselard, Marion
Balès, Mélanie
Sutter-Dallay, Anne-Laure
Fromage, Dominique
Spitz, Elisabeth
Dallay, Dominique
Harvey, Thierry
Welter, Eric
Coatleven, Frédéric
Cherier, Lydie
Teissèdre, Frédérique
Pouly, Jean-Luc
Dutheil, Frédéric
Duffaud, Anaïs M
author_sort Tharwat, Dahlia
collection PubMed
description INTRODUCTION: The prevalence of postnatal depression (PND) is significant: reaching up to 20% in the general population. In mechanistic terms, the risk of PND lies in an interaction between a maternal psychophysiological vulnerability and a chronic environmental context of stress. On the one hand, repetition of stressor during pregnancy mimics a chronic stress model that is relevant to the study of the allostatic load and the adaptive mechanisms. On the other hand, vulnerability factors reflect a psychological profile mirroring mindfulness functioning (psychological quality that involves bringing one’s complete and non-judgemental attention to the present experience on a moment-to-moment basis). This psychological resource is linked to protective and resilient psychic functioning. Thus, PND appears to be a relevant model for studying the mechanisms of chronic stress and vulnerability to psychopathologies. In this article, we present the protocol of an ongoing study (started in May 2017). METHODS AND ANALYSIS: The study is being carried out in five maternities and will involve 260 women. We aim to determine the predictive psychobiological factors for PND emergence and to provide a better insight into the mechanisms involved in chronic stress during pregnancy. We use a multidisciplinary approach that encompasses psychological resources and biophysiological and genetic profiles in order to detect relevant vulnerability biomarkers for chronic stress and the development of PND. To do so, each woman will be involved in the study from her first trimester of pregnancy until 12 months postdelivery. ETHICS AND DISSEMINATION: Ethics approval was obtained from the Ile de France III Ethics Committee, France (2016-A00887-44). We aim to disseminate the findings through international conferences and international peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT03088319; Pre-results.
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spelling pubmed-59424202018-05-11 Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study Tharwat, Dahlia Trousselard, Marion Balès, Mélanie Sutter-Dallay, Anne-Laure Fromage, Dominique Spitz, Elisabeth Dallay, Dominique Harvey, Thierry Welter, Eric Coatleven, Frédéric Cherier, Lydie Teissèdre, Frédérique Pouly, Jean-Luc Dutheil, Frédéric Duffaud, Anaïs M BMJ Open Mental Health INTRODUCTION: The prevalence of postnatal depression (PND) is significant: reaching up to 20% in the general population. In mechanistic terms, the risk of PND lies in an interaction between a maternal psychophysiological vulnerability and a chronic environmental context of stress. On the one hand, repetition of stressor during pregnancy mimics a chronic stress model that is relevant to the study of the allostatic load and the adaptive mechanisms. On the other hand, vulnerability factors reflect a psychological profile mirroring mindfulness functioning (psychological quality that involves bringing one’s complete and non-judgemental attention to the present experience on a moment-to-moment basis). This psychological resource is linked to protective and resilient psychic functioning. Thus, PND appears to be a relevant model for studying the mechanisms of chronic stress and vulnerability to psychopathologies. In this article, we present the protocol of an ongoing study (started in May 2017). METHODS AND ANALYSIS: The study is being carried out in five maternities and will involve 260 women. We aim to determine the predictive psychobiological factors for PND emergence and to provide a better insight into the mechanisms involved in chronic stress during pregnancy. We use a multidisciplinary approach that encompasses psychological resources and biophysiological and genetic profiles in order to detect relevant vulnerability biomarkers for chronic stress and the development of PND. To do so, each woman will be involved in the study from her first trimester of pregnancy until 12 months postdelivery. ETHICS AND DISSEMINATION: Ethics approval was obtained from the Ile de France III Ethics Committee, France (2016-A00887-44). We aim to disseminate the findings through international conferences and international peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT03088319; Pre-results. BMJ Publishing Group 2018-05-03 /pmc/articles/PMC5942420/ /pubmed/29724735 http://dx.doi.org/10.1136/bmjopen-2017-018317 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Mental Health
Tharwat, Dahlia
Trousselard, Marion
Balès, Mélanie
Sutter-Dallay, Anne-Laure
Fromage, Dominique
Spitz, Elisabeth
Dallay, Dominique
Harvey, Thierry
Welter, Eric
Coatleven, Frédéric
Cherier, Lydie
Teissèdre, Frédérique
Pouly, Jean-Luc
Dutheil, Frédéric
Duffaud, Anaïs M
Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study
title Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study
title_full Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study
title_fullStr Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study
title_full_unstemmed Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study
title_short Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study
title_sort chronic stress protection for postnatal depression prevention (serene): a protocol for an exploratory study
topic Mental Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942420/
https://www.ncbi.nlm.nih.gov/pubmed/29724735
http://dx.doi.org/10.1136/bmjopen-2017-018317
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