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Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study

BACKGROUND: It is supposed that hypoandrogenism may be involved in the pathogenesis of rheumatoid arthritis (RA). Testosterone and dehydroepiandrosterone sulfate (DHEAs) levels decrease in body fluids of patients with RA. OBJECTIVE: The aim of this study was to determine the association of serum tes...

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Autores principales: Lashkari, Mahin, Noori, Akram, Oveisi, Sonia, Kheirkhah, Mohammadreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Electronic physician 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942571/
https://www.ncbi.nlm.nih.gov/pubmed/29765575
http://dx.doi.org/10.19082/6500
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author Lashkari, Mahin
Noori, Akram
Oveisi, Sonia
Kheirkhah, Mohammadreza
author_facet Lashkari, Mahin
Noori, Akram
Oveisi, Sonia
Kheirkhah, Mohammadreza
author_sort Lashkari, Mahin
collection PubMed
description BACKGROUND: It is supposed that hypoandrogenism may be involved in the pathogenesis of rheumatoid arthritis (RA). Testosterone and dehydroepiandrosterone sulfate (DHEAs) levels decrease in body fluids of patients with RA. OBJECTIVE: The aim of this study was to determine the association of serum testosterone and DHEAs with RA. METHODS: This case-control study was conducted on 59 patients with RA and 61 healthy gender- and age-matched controls at Qazvin University of Medical Sciences, Qazvin, Iran, in 2014. Serum free testosterone and DHEAs levels were measured and compared between two groups. Serum testosterone levels lower than 0.029 ng/ml in females and 2.49 ng/ml in males were considered as abnormal. DHEAs levels lower than 18.9 μg/dl in females and 88.9 μg/dl in males were considered as abnormal. Data were analyzed using independent sample T-test, Chi-square test, and logistic regression analysis by SPSS software, version 19. RESULTS: The mean testosterone level in females of the control group was significantly higher than females in the case group. The mean DHEAs in the control group was significantly higher than the case group. Abnormal testosterone and DHEAs level in the case group was significantly higher than the control group. Logistic regression analysis showed independent association only between DHEAs levels and RA, after adjusting for age and gender (OR: 0.966, 95% CI: 0.953–0.979; p<0.001). CONCLUSION: With regard to the results, abnormal testosterone and DHEAs level in patients with RA was significantly higher than the control group. This shows the anti-inflammatory effects of gonadal and adrenal androgens in RA.
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spelling pubmed-59425712018-05-15 Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study Lashkari, Mahin Noori, Akram Oveisi, Sonia Kheirkhah, Mohammadreza Electron Physician Original Article BACKGROUND: It is supposed that hypoandrogenism may be involved in the pathogenesis of rheumatoid arthritis (RA). Testosterone and dehydroepiandrosterone sulfate (DHEAs) levels decrease in body fluids of patients with RA. OBJECTIVE: The aim of this study was to determine the association of serum testosterone and DHEAs with RA. METHODS: This case-control study was conducted on 59 patients with RA and 61 healthy gender- and age-matched controls at Qazvin University of Medical Sciences, Qazvin, Iran, in 2014. Serum free testosterone and DHEAs levels were measured and compared between two groups. Serum testosterone levels lower than 0.029 ng/ml in females and 2.49 ng/ml in males were considered as abnormal. DHEAs levels lower than 18.9 μg/dl in females and 88.9 μg/dl in males were considered as abnormal. Data were analyzed using independent sample T-test, Chi-square test, and logistic regression analysis by SPSS software, version 19. RESULTS: The mean testosterone level in females of the control group was significantly higher than females in the case group. The mean DHEAs in the control group was significantly higher than the case group. Abnormal testosterone and DHEAs level in the case group was significantly higher than the control group. Logistic regression analysis showed independent association only between DHEAs levels and RA, after adjusting for age and gender (OR: 0.966, 95% CI: 0.953–0.979; p<0.001). CONCLUSION: With regard to the results, abnormal testosterone and DHEAs level in patients with RA was significantly higher than the control group. This shows the anti-inflammatory effects of gonadal and adrenal androgens in RA. Electronic physician 2018-03-25 /pmc/articles/PMC5942571/ /pubmed/29765575 http://dx.doi.org/10.19082/6500 Text en © 2018 The Authors This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/3.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Original Article
Lashkari, Mahin
Noori, Akram
Oveisi, Sonia
Kheirkhah, Mohammadreza
Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study
title Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study
title_full Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study
title_fullStr Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study
title_full_unstemmed Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study
title_short Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study
title_sort association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoid arthritis: a case control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942571/
https://www.ncbi.nlm.nih.gov/pubmed/29765575
http://dx.doi.org/10.19082/6500
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