Cargando…

Increased α-actinin-1 destabilizes E-cadherin-based adhesions and associates with poor prognosis in basal-like breast cancer

The controlled formation and stabilization of E-cadherin-based adhesions is vital for epithelial integrity. This requires co-operation between the E-cadherin-based adhesions and the associated actin cytoskeleton. In cancer, this co-operation often fails, predisposing cells to migration through molec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kovac, Bianca, Mäkelä, Tomi P., Vallenius, Tea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942811/ https://www.ncbi.nlm.nih.gov/pubmed/29742177 http://dx.doi.org/10.1371/journal.pone.0196986

Ejemplares similares

SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling
por: Yan, Yan, et al.
Publicado: (2015)

Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin
Publicado: (1995)

Flotillins Regulate Focal Adhesions by Interacting with α-Actinin and by Influencing the Activation of Focal Adhesion Kinase
por: Banning, Antje, et al.
Publicado: (2018)

Cyclin G-associated kinase promotes microtubule outgrowth from chromosomes during spindle assembly
por: Tanenbaum, Marvin E., et al.
Publicado: (2010)

Characterisation of Schizosaccharomyces pombe α-actinin
por: Addario, Barbara, et al.
Publicado: (2016)

Actin stress fibre subtypes in mesenchymal-migrating cells
por: Vallenius, Tea
Publicado: (2013)

α-Actinin-4 Enhances Colorectal Cancer Cell Invasion by Suppressing Focal Adhesion Maturation
por: Fukumoto, Miki, et al.
Publicado: (2015)

Differential Dynamics of α5 Integrin, Paxillin, and α-Actinin during Formation and Disassembly of Adhesions in Migrating Cells
por: Laukaitis, Christina M., et al.
Publicado: (2001)

Characterization of the interaction between Actinin-Associated LIM Protein (ALP) and the rod domain of α-actinin
por: Klaavuniemi, Tuula, et al.
Publicado: (2009)

Calcium affinity of human α-actinin 1
por: Backman, Lars
Publicado: (2015)

The Structure and Regulation of Human Muscle α-Actinin
por: Ribeiro, Euripedes de Almeida, et al.
Publicado: (2014)

The domain structure of Entamoeba α-actinin2
por: Addario, Barbara, et al.
Publicado: (2010)

α-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes
por: Tseng, Chien-Chun, et al.
Publicado: (2022)

Podocyte Injury Associated with Mutant α-Actinin-4
por: Cybulsky, Andrey V., et al.
Publicado: (2011)

Limited digestion of α-actinin in the presence of F-actin
por: Jia, You, et al.
Publicado: (2011)

E-Cadherin Destabilization Accounts for the Pathogenicity of Missense Mutations in Hereditary Diffuse Gastric Cancer
por: Simões-Correia, Joana, et al.
Publicado: (2012)

E-cadherin expression in basal cell carcinoma.
por: Pizarro, A., et al.
Publicado: (1994)

Distribution of flourescently labeled α-actinin in living and fixed fibroblasts
por: Feramisco,, et al.
Publicado: (1980)

HAMLET Binding to α-Actinin Facilitates Tumor Cell Detachment
por: Trulsson, Maria, et al.
Publicado: (2011)

Isoform-Specific Contributions of α-Actinin to Glioma Cell Mechanobiology
por: Sen, Shamik, et al.
Publicado: (2009)

α-Actinin-3: Why Gene Loss Is an Evolutionary Gain
por: Ivarsson, Niklas, et al.
Publicado: (2015)

Muscleblind-like 1 destabilizes Snail mRNA and suppresses the metastasis of colorectal cancer cells via the Snail/E-cadherin axis
por: Tang, Liang, et al.
Publicado: (2019)

Structure and calcium-binding studies of calmodulin-like domain of human non-muscle α-actinin-1
por: Drmota Prebil, Sara, et al.
Publicado: (2016)

Molecular Basis for Leukocyte Integrin α(E)β(7) Adhesion to Epithelial (E)-Cadherin
por: Taraszka, Karen S., et al.
Publicado: (2000)

α-Catenin Dependent E-cadherin Adhesion Dynamics as Revealed by an Accelerated Force Ramp
por: Bush, Joshua, et al.
Publicado: (2023)

ME1 promotes basal-like breast cancer progression and associates with poor prognosis
por: Liao, Ruocen, et al.
Publicado: (2018)

α-catenin acts as a tumor suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signaling
por: Piao, Hai-long, et al.
Publicado: (2014)

α-Actinin and Filamin Cooperatively Enhance the Stiffness of Actin Filament Networks
por: Esue, Osigwe, et al.
Publicado: (2009)

α-Actinin-4 Is Essential for Maintaining the Spreading, Motility and Contractility of Fibroblasts
por: Shao, Hanshuang, et al.
Publicado: (2010)

Neisseria meningitidis Opc invasin binds to the cytoskeletal protein α-actinin
por: Sa E Cunha, Claudia, et al.
Publicado: (2009)

The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis
por: Youinou, Pierre, et al.
Publicado: (2009)

Epithelial Cell-Like Elasticity Modulates Actin-Dependent E-Cadherin Adhesion Organization
por: Eftekharjoo, Mohamad, et al.
Publicado: (2022)

ERβ1 represses basal-like breast cancer epithelial to mesenchymal transition by destabilizing EGFR
por: Thomas, Christoforos, et al.
Publicado: (2012)

Restructuring of Focal Adhesion Plaques by Pi 3-Kinase: Regulation by Ptdins (3,4,5-P)(3) Binding to α-Actinin
por: Greenwood, Jeffrey A., et al.
Publicado: (2000)

αE-catenin regulates actin dynamics independently of cadherin-mediated cell–cell adhesion
por: Benjamin, Jacqueline M., et al.
Publicado: (2010)

α-catenin, vinculin, and F-actin in strengthening E-cadherin cell–cell adhesions and mechanosensing
por: Dufour, Sylvie, et al.
Publicado: (2013)

Association of intercellular adhesion molecule-1 (ICAM-1) with actin- containing cytoskeleton and alpha-actinin
Publicado: (1992)

The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3
por: Agarwal, Sunita K, et al.
Publicado: (2008)

Regulation of Cadherin Adhesive Activity
por: Gumbiner, Barry M.
Publicado: (2000)

Tuning the kinetics of cadherin adhesion
por: Sivasankar, Sanjeevi
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_7lcilvvt0lctqbpuj68qevnlrp