Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration

Nematode EAK-7 (enhancer-of-akt-1-7) regulates dauer formation and controls life span; however, the function of the human ortholog mammalian EAK-7 (mEAK-7) is unknown. We report that mEAK-7 activates an alternative mechanistic/mammalian target of rapamycin (mTOR) signaling pathway in human cells, in...

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Detalles Bibliográficos
Autores principales: Nguyen, Joe Truong, Ray, Connor, Fox, Alexandra Lucienne, Mendonça, Daniela Baccelli, Kim, Jin Koo, Krebsbach, Paul H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942914/
https://www.ncbi.nlm.nih.gov/pubmed/29750193
http://dx.doi.org/10.1126/sciadv.aao5838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942914/
https://www.ncbi.nlm.nih.gov/pubmed/29750193
http://dx.doi.org/10.1126/sciadv.aao5838

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