Silencing of transposable elements may not be a major driver of regulatory evolution in primate iPSCs

Transposable elements (TEs) comprise almost half of primate genomes and their aberrant regulation can result in deleterious effects. In pluripotent stem cells, rapidly evolving KRAB-ZNF genes target TEs for silencing by H3K9me3. To investigate the evolution of TE silencing, we performed H3K9me3 ChIP...

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Detalles Bibliográficos
Autores principales: Ward, Michelle C, Zhao, Siming, Luo, Kaixuan, Pavlovic, Bryan J, Karimi, Mohammad M, Stephens, Matthew, Gilad, Yoav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943035/
https://www.ncbi.nlm.nih.gov/pubmed/29648536
http://dx.doi.org/10.7554/eLife.33084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943035/
https://www.ncbi.nlm.nih.gov/pubmed/29648536
http://dx.doi.org/10.7554/eLife.33084

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