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Comparison of Cortical and Subcortical Measurements in Normal Older Adults across Databases and Software Packages
This work explores the feasibility of combining anatomical MRI data across two public repositories namely, the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Progressive Parkinson’s Markers Initiative (PPMI). We compared cortical thickness and subcortical volumes in cognitively normal ol...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943040/ https://www.ncbi.nlm.nih.gov/pubmed/29756095 http://dx.doi.org/10.3233/ADR-170008 |
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author | Rane, Swati Plassard, Andrew Landman, Bennett A. Claassen, Daniel O. Donahue, Manus J. |
author_facet | Rane, Swati Plassard, Andrew Landman, Bennett A. Claassen, Daniel O. Donahue, Manus J. |
author_sort | Rane, Swati |
collection | PubMed |
description | This work explores the feasibility of combining anatomical MRI data across two public repositories namely, the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Progressive Parkinson’s Markers Initiative (PPMI). We compared cortical thickness and subcortical volumes in cognitively normal older adults between datasets with distinct imaging parameters to assess if they would provide equivalent information. Three distinct datasets were identified. Major differences in data were scanner manufacturer and the use of magnetization inversion to enhance tissue contrast. Equivalent datasets, i.e., those providing similar volumetric measurements in cognitively normal controls, were identified in ADNI and PPMI. These were datasets obtained on the Siemens scanner with TI = 900 ms. Our secondary goal was to assess the agreement between subcortical volumes that are obtained with different software packages. Three subcortical measurement applications (FSL, FreeSurfer, and a recent multi-atlas approach) were compared. Our results show significant agreement in the measurements of caudate, putamen, pallidum, and hippocampus across the packages and poor agreement between measurements of accumbens and amygdala. This is likely due to their smaller size and lack of gray matter-white matter tissue contrast for accurate segmentation. This work provides a segue to combine imaging data from ADNI and PPMI to increase statistical power as well as to interrogate common mechanisms in disparate pathologies such as Alzheimer’s and Parkinson’s diseases. It lays the foundation for comparison of anatomical data acquired with disparate imaging parameters and analyzed with disparate software tools. Furthermore, our work partly explains the variability in the results of studies using different software packages. |
format | Online Article Text |
id | pubmed-5943040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59430402018-05-09 Comparison of Cortical and Subcortical Measurements in Normal Older Adults across Databases and Software Packages Rane, Swati Plassard, Andrew Landman, Bennett A. Claassen, Daniel O. Donahue, Manus J. J Alzheimers Dis Rep Research Article This work explores the feasibility of combining anatomical MRI data across two public repositories namely, the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Progressive Parkinson’s Markers Initiative (PPMI). We compared cortical thickness and subcortical volumes in cognitively normal older adults between datasets with distinct imaging parameters to assess if they would provide equivalent information. Three distinct datasets were identified. Major differences in data were scanner manufacturer and the use of magnetization inversion to enhance tissue contrast. Equivalent datasets, i.e., those providing similar volumetric measurements in cognitively normal controls, were identified in ADNI and PPMI. These were datasets obtained on the Siemens scanner with TI = 900 ms. Our secondary goal was to assess the agreement between subcortical volumes that are obtained with different software packages. Three subcortical measurement applications (FSL, FreeSurfer, and a recent multi-atlas approach) were compared. Our results show significant agreement in the measurements of caudate, putamen, pallidum, and hippocampus across the packages and poor agreement between measurements of accumbens and amygdala. This is likely due to their smaller size and lack of gray matter-white matter tissue contrast for accurate segmentation. This work provides a segue to combine imaging data from ADNI and PPMI to increase statistical power as well as to interrogate common mechanisms in disparate pathologies such as Alzheimer’s and Parkinson’s diseases. It lays the foundation for comparison of anatomical data acquired with disparate imaging parameters and analyzed with disparate software tools. Furthermore, our work partly explains the variability in the results of studies using different software packages. IOS Press 2017-07-19 /pmc/articles/PMC5943040/ /pubmed/29756095 http://dx.doi.org/10.3233/ADR-170008 Text en IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Rane, Swati Plassard, Andrew Landman, Bennett A. Claassen, Daniel O. Donahue, Manus J. Comparison of Cortical and Subcortical Measurements in Normal Older Adults across Databases and Software Packages |
title | Comparison of Cortical and Subcortical Measurements in Normal Older Adults across Databases and Software Packages |
title_full | Comparison of Cortical and Subcortical Measurements in Normal Older Adults across Databases and Software Packages |
title_fullStr | Comparison of Cortical and Subcortical Measurements in Normal Older Adults across Databases and Software Packages |
title_full_unstemmed | Comparison of Cortical and Subcortical Measurements in Normal Older Adults across Databases and Software Packages |
title_short | Comparison of Cortical and Subcortical Measurements in Normal Older Adults across Databases and Software Packages |
title_sort | comparison of cortical and subcortical measurements in normal older adults across databases and software packages |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943040/ https://www.ncbi.nlm.nih.gov/pubmed/29756095 http://dx.doi.org/10.3233/ADR-170008 |
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