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Neuroprotective effect of ethanol in acute carbon monoxide intoxication: A retrospective study
In acute carbon monoxide (CO) intoxication, treatment of neurologic injury and prevention of neurological sequelae are primary concerns. Ethanol is the one of the frequent substances which is co-ingested in intentional CO poisoning. Neuroprotective effect of ethanol was highlighted and demonstrated...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943126/ https://www.ncbi.nlm.nih.gov/pubmed/29505539 http://dx.doi.org/10.1097/MD.0000000000009569 |
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author | Kim, Hyuk-Hoon Choi, Sang Chun Chae, Minjung Kathy Min, Young-Gi |
author_facet | Kim, Hyuk-Hoon Choi, Sang Chun Chae, Minjung Kathy Min, Young-Gi |
author_sort | Kim, Hyuk-Hoon |
collection | PubMed |
description | In acute carbon monoxide (CO) intoxication, treatment of neurologic injury and prevention of neurological sequelae are primary concerns. Ethanol is the one of the frequent substances which is co-ingested in intentional CO poisoning. Neuroprotective effect of ethanol was highlighted and demonstrated in isolated brain injury recently. We assessed the neuroprotective effect of ethanol in acute CO intoxication using magnetic resonance imaging (MRI). We retrospectively reviewed medical records for patients who visited an emergency medical center of a university-affiliated hospital during a period of 73 months, from March 2009 to April 2015. Enrolled patients were divided into 2 groups, patients with or without abnormal brain lesion in brain MRI. Multivariate logistic regression analysis was performed to assess the factors associated with brain injury in MRI. A total of 109 patients with acute CO intoxication were evaluated of which 66 (60.55%) tested positive in brain MRI. MRI lesion-positive patients were more likely to have electrocardiogram change, elevation of serum troponin I and s100 protein level and lower serum ethanol level. Serum ethanol positivity was an independent factor for prevalence of brain injury in MRI in acute CO poisoning. This study revealed that ethanol which is co-ingested in acute CO intoxication may work the neuroprotective effect and could consequence more favorable neurological outcome in acute CO intoxication. |
format | Online Article Text |
id | pubmed-5943126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-59431262018-05-15 Neuroprotective effect of ethanol in acute carbon monoxide intoxication: A retrospective study Kim, Hyuk-Hoon Choi, Sang Chun Chae, Minjung Kathy Min, Young-Gi Medicine (Baltimore) Research Article In acute carbon monoxide (CO) intoxication, treatment of neurologic injury and prevention of neurological sequelae are primary concerns. Ethanol is the one of the frequent substances which is co-ingested in intentional CO poisoning. Neuroprotective effect of ethanol was highlighted and demonstrated in isolated brain injury recently. We assessed the neuroprotective effect of ethanol in acute CO intoxication using magnetic resonance imaging (MRI). We retrospectively reviewed medical records for patients who visited an emergency medical center of a university-affiliated hospital during a period of 73 months, from March 2009 to April 2015. Enrolled patients were divided into 2 groups, patients with or without abnormal brain lesion in brain MRI. Multivariate logistic regression analysis was performed to assess the factors associated with brain injury in MRI. A total of 109 patients with acute CO intoxication were evaluated of which 66 (60.55%) tested positive in brain MRI. MRI lesion-positive patients were more likely to have electrocardiogram change, elevation of serum troponin I and s100 protein level and lower serum ethanol level. Serum ethanol positivity was an independent factor for prevalence of brain injury in MRI in acute CO poisoning. This study revealed that ethanol which is co-ingested in acute CO intoxication may work the neuroprotective effect and could consequence more favorable neurological outcome in acute CO intoxication. Wolters Kluwer Health 2018-01-05 /pmc/articles/PMC5943126/ /pubmed/29505539 http://dx.doi.org/10.1097/MD.0000000000009569 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0 |
spellingShingle | Research Article Kim, Hyuk-Hoon Choi, Sang Chun Chae, Minjung Kathy Min, Young-Gi Neuroprotective effect of ethanol in acute carbon monoxide intoxication: A retrospective study |
title | Neuroprotective effect of ethanol in acute carbon monoxide intoxication: A retrospective study |
title_full | Neuroprotective effect of ethanol in acute carbon monoxide intoxication: A retrospective study |
title_fullStr | Neuroprotective effect of ethanol in acute carbon monoxide intoxication: A retrospective study |
title_full_unstemmed | Neuroprotective effect of ethanol in acute carbon monoxide intoxication: A retrospective study |
title_short | Neuroprotective effect of ethanol in acute carbon monoxide intoxication: A retrospective study |
title_sort | neuroprotective effect of ethanol in acute carbon monoxide intoxication: a retrospective study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943126/ https://www.ncbi.nlm.nih.gov/pubmed/29505539 http://dx.doi.org/10.1097/MD.0000000000009569 |
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