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Mitochondrial Complex I activity signals antioxidant response through ERK5

Oxidative phosphorylation (OXPHOS) generates ROS as a byproduct of mitochondrial complex I activity. ROS-detoxifying enzymes are made available through the activation of their antioxidant response elements (ARE) in their gene promoters. NRF2 binds to AREs and induces this anti-oxidant response. We s...

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Detalles Bibliográficos
Autores principales:	Khan, Abrar Ul Haq, Allende-Vega, Nerea, Gitenay, Delphine, Garaude, Johan, Vo, Dang-Nghiem, Belkhala, Sana, Gerbal-Chaloin, Sabine, Gondeau, Claire, Daujat-Chavanieu, Martine, Delettre, Cécile, Orecchioni, Stefania, Talarico, Giovanna, Bertolini, Francesco, Anel, Alberto, Cuezva, José M., Enriquez, Jose A., Cartron, Guillaume, Lecellier, Charles-Henri, Hernandez, Javier, Villalba, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943249/ https://www.ncbi.nlm.nih.gov/pubmed/29743487 http://dx.doi.org/10.1038/s41598-018-23884-4

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