Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted

Mixed lineage kinase domain-like (MLKL)-dependent necroptosis is thought to be implicated in the death of mycobacteria-infected macrophages, reportedly allowing escape and dissemination of the microorganism. Given the consequent interest in developing inhibitors of necroptosis to treat Mycobacterium...

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Detalles Bibliográficos
Autores principales: Stutz, Michael D., Ojaimi, Samar, Allison, Cody, Preston, Simon, Arandjelovic, Philip, Hildebrand, Joanne M., Sandow, Jarrod J., Webb, Andrew I., Silke, John, Alexander, Warren S., Pellegrini, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943269/
https://www.ncbi.nlm.nih.gov/pubmed/29229989
http://dx.doi.org/10.1038/s41418-017-0031-1

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