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Impact of UGT1A1 polymorphisms on Raltegravir and its glucuronide plasma concentrations in a cohort of HIV-1 infected patients
The aim of this study was to evaluate the effect of UGT1A1 polymorphisms on Raltegravir (RAL) and its metabolite RAL-glucuronide trough plasma concentrations ([RAL]plasma and [RAL-glu]plasma) and on the metabolic ratio (MR): [RAL-glu]plasma/[RAL]plasma. UGT1A1 genotyping was performed on 96 patients...
Autores principales: | Belkhir, Leïla, Seguin-Devaux, Carole, Elens, Laure, Pauly, Caroline, Gengler, Nicolas, Schneider, Serge, Ruelle, Jean, Haufroid, Vincent, Vandercam, Bernard |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943329/ https://www.ncbi.nlm.nih.gov/pubmed/29743555 http://dx.doi.org/10.1038/s41598-018-25803-z |
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