RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly

Intracellular membrane trafficking is essential for eukaryotic cell existence. Here, we show that RAB37 activation through GTP binding recruits ATG5-12 to isolation membrane and promotes autophagosome formation through the ATG5-ATG12-ATG16L1 complex. RAB37 is localized on the isolation membrane. It...

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Detalles Bibliográficos
Autores principales: Sheng, Yue, Song, Ying, Li, Zhigang, Wang, Yabo, Lin, Heming, Cheng, Hanhua, Zhou, Rongjia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943352/
https://www.ncbi.nlm.nih.gov/pubmed/29229996
http://dx.doi.org/10.1038/s41418-017-0023-1

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