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Tumor‐derived extracellular vesicles activate primary monocytes
Tumor cells educate immune effector cells in their vicinity by releasing factors that manipulate their phenotype and function. In fact, the thus generated immunosuppressive tumor microenvironment constitutes an integral part and a hallmark of solid tumors and contributes significantly to tumor devel...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943417/ https://www.ncbi.nlm.nih.gov/pubmed/29601673 http://dx.doi.org/10.1002/cam4.1465 |
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author | Gärtner, Kathrin Battke, Christina Dünzkofer, Judith Hüls, Corinna von Neubeck, Bettina Kellner, Mar‐ kus Fiestas, Elena Fackler, Susanne Lang, Stephan Zeidler, Reinhard |
author_facet | Gärtner, Kathrin Battke, Christina Dünzkofer, Judith Hüls, Corinna von Neubeck, Bettina Kellner, Mar‐ kus Fiestas, Elena Fackler, Susanne Lang, Stephan Zeidler, Reinhard |
author_sort | Gärtner, Kathrin |
collection | PubMed |
description | Tumor cells educate immune effector cells in their vicinity by releasing factors that manipulate their phenotype and function. In fact, the thus generated immunosuppressive tumor microenvironment constitutes an integral part and a hallmark of solid tumors and contributes significantly to tumor development and immune escape. It has long been thought that soluble factors like prostaglandin E2 and TGF‐β are the main mediators of these effects. But tumor cells also constantly release large number of extracellular vesicles (EVs), which are important conveyors of immune responses. We show here that tumor‐derived EVs interact with primary monocytes and induce an activated phenotype, which is also observed in tumor‐associated macrophages. Thus, both tumor‐derived EVs and soluble factors together collaborate to form the immunosuppressive milieu of the tumor environment. |
format | Online Article Text |
id | pubmed-5943417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59434172018-05-14 Tumor‐derived extracellular vesicles activate primary monocytes Gärtner, Kathrin Battke, Christina Dünzkofer, Judith Hüls, Corinna von Neubeck, Bettina Kellner, Mar‐ kus Fiestas, Elena Fackler, Susanne Lang, Stephan Zeidler, Reinhard Cancer Med Cancer Biology Tumor cells educate immune effector cells in their vicinity by releasing factors that manipulate their phenotype and function. In fact, the thus generated immunosuppressive tumor microenvironment constitutes an integral part and a hallmark of solid tumors and contributes significantly to tumor development and immune escape. It has long been thought that soluble factors like prostaglandin E2 and TGF‐β are the main mediators of these effects. But tumor cells also constantly release large number of extracellular vesicles (EVs), which are important conveyors of immune responses. We show here that tumor‐derived EVs interact with primary monocytes and induce an activated phenotype, which is also observed in tumor‐associated macrophages. Thus, both tumor‐derived EVs and soluble factors together collaborate to form the immunosuppressive milieu of the tumor environment. John Wiley and Sons Inc. 2018-03-30 /pmc/articles/PMC5943417/ /pubmed/29601673 http://dx.doi.org/10.1002/cam4.1465 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cancer Biology Gärtner, Kathrin Battke, Christina Dünzkofer, Judith Hüls, Corinna von Neubeck, Bettina Kellner, Mar‐ kus Fiestas, Elena Fackler, Susanne Lang, Stephan Zeidler, Reinhard Tumor‐derived extracellular vesicles activate primary monocytes |
title | Tumor‐derived extracellular vesicles activate primary monocytes |
title_full | Tumor‐derived extracellular vesicles activate primary monocytes |
title_fullStr | Tumor‐derived extracellular vesicles activate primary monocytes |
title_full_unstemmed | Tumor‐derived extracellular vesicles activate primary monocytes |
title_short | Tumor‐derived extracellular vesicles activate primary monocytes |
title_sort | tumor‐derived extracellular vesicles activate primary monocytes |
topic | Cancer Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943417/ https://www.ncbi.nlm.nih.gov/pubmed/29601673 http://dx.doi.org/10.1002/cam4.1465 |
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