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Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer
PP2A is a major tumor suppressor whose inactivation is frequently found in a wide spectrum of human tumors. In particular, deletion or epigenetic silencing of genes encoding the B55 family of PP2A regulatory subunits is a common feature of breast cancer cells. A key player in the regulation of PP2A/...
Autores principales: | Álvarez-Fernández, Mónica, Sanz-Flores, María, Sanz-Castillo, Belén, Salazar-Roa, María, Partida, David, Zapatero-Solana, Elisabet, Ali, H. Raza, Manchado, Eusebio, Lowe, Scott, VanArsdale, Todd, Shields, David, Caldas, Carlos, Quintela-Fandino, Miguel, Malumbres, Marcos |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943447/ https://www.ncbi.nlm.nih.gov/pubmed/29229993 http://dx.doi.org/10.1038/s41418-017-0024-0 |
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