NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

Senescent cells interact with the surrounding microenvironment achieving diverse functional outcomes. We have recently identified that NOTCH1 can drive ‘lateral induction’ of a unique senescence phenotype in adjacent cells by specifically upregulating the NOTCH ligand JAG1. Here we show that NOTCH s...

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Detalles Bibliográficos
Autores principales: Parry, Aled J., Hoare, Matthew, Bihary, Dóra, Hänsel-Hertsch, Robert, Smith, Stephen, Tomimatsu, Kosuke, Mannion, Elizabeth, Smith, Amy, D’Santos, Paula, Russell, I. Alasdair, Balasubramanian, Shankar, Kimura, Hiroshi, Samarajiwa, Shamith A., Narita, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943456/
https://www.ncbi.nlm.nih.gov/pubmed/29743479
http://dx.doi.org/10.1038/s41467-018-04283-9

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