Germline MLH1, MSH2 and MSH6 variants in Brazilian patients with colorectal cancer and clinical features suggestive of Lynch Syndrome

Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by germline mutations in one of the major genes involved in mismatch repair (MMR): MLH1,MSH2,MSH6 and more rarely, PMS2. Recently, germline deletions in EPCAM have been also associated to the syndrome. Most of the p...

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Detalles Bibliográficos
Autores principales: Schneider, Nayê Balzan, Pastor, Tatiane, de Paula, André Escremim, Achatz, Maria Isabel, dos Santos, Ândrea Ribeiro, Vianna, Fernanda Sales Luiz, Rosset, Clévia, Pinheiro, Manuela, Ashton‐Prolla, Patricia, Moreira, Miguel Ângelo Martins, Palmero, Edenir Inêz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943474/
https://www.ncbi.nlm.nih.gov/pubmed/29575718
http://dx.doi.org/10.1002/cam4.1316

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