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A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women

Advanced glycation end products (AGEs) dysregulate adipokines and induce inflammation by binding to their adipocyte receptor (RAGE). Soluble RAGE (sRAGE) prevents AGEs/RAGE signaling. We performed a nested case–control study of the association between sRAGE, adipokines, and incident pancreatic cance...

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Autores principales: White, Donna L., Hoogeveen, Ron C., Chen, Liang, Richardson, Peter, Ravishankar, Milan, Shah, Preksha, Tinker, Lesley, Rohan, Thomas, Whitsel, Eric A., El‐Serag, Hashem B., Jiao, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943487/
https://www.ncbi.nlm.nih.gov/pubmed/29573228
http://dx.doi.org/10.1002/cam4.1426
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author White, Donna L.
Hoogeveen, Ron C.
Chen, Liang
Richardson, Peter
Ravishankar, Milan
Shah, Preksha
Tinker, Lesley
Rohan, Thomas
Whitsel, Eric A.
El‐Serag, Hashem B.
Jiao, Li
author_facet White, Donna L.
Hoogeveen, Ron C.
Chen, Liang
Richardson, Peter
Ravishankar, Milan
Shah, Preksha
Tinker, Lesley
Rohan, Thomas
Whitsel, Eric A.
El‐Serag, Hashem B.
Jiao, Li
author_sort White, Donna L.
collection PubMed
description Advanced glycation end products (AGEs) dysregulate adipokines and induce inflammation by binding to their adipocyte receptor (RAGE). Soluble RAGE (sRAGE) prevents AGEs/RAGE signaling. We performed a nested case–control study of the association between sRAGE, adipokines, and incident pancreatic cancer risk in the prospective Women's Health Initiative Study. We individually matched controls (n = 802) to cases (n = 472) on age, race, and blood draw date. We evaluated serum concentrations of sRAGE, adiponectin, leptin, monocyte chemotactic protein 1 (MCP1), and plasminogen activator inhibitor‐1 (PAI1) using immunoassay. We used conditional logistic regression model to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for pancreatic cancer over biomarker quartiles (Q1–Q4). We used principal component analysis to create two composite biomarkers and performed a confirmatory factor analysis to examine the association between composite biomarker scores (CBS) and pancreatic cancer risk. Baseline serum sRAGE concentrations were inversely associated with pancreatic cancer risk (aOR(Q4 vs. Q1 )= 0.70, 95% CI: 0.50–0.99). High MCP1 (aOR (Q4 vs. Q1 )= 2.55, 95% CI: 1.41–4.61) and the higher CBS including MCP1, PAI1, and leptin (aOR(Q4 vs. Q1 )= 1.82, 95% CI = 1.04–3.18) were also associated with increased pancreatic cancer risk among women with BMI <25 kg/m(2) (P values for interaction <0.05). We found an inverse association between prediagnostic sRAGE concentrations and risk of incident pancreatic cancer in postmenopausal women. A proinflammatory CBS was associated with increased risk only in women with normal BMI. MCP1 was not modulated by sRAGE.
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spelling pubmed-59434872018-05-14 A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women White, Donna L. Hoogeveen, Ron C. Chen, Liang Richardson, Peter Ravishankar, Milan Shah, Preksha Tinker, Lesley Rohan, Thomas Whitsel, Eric A. El‐Serag, Hashem B. Jiao, Li Cancer Med Cancer Prevention Advanced glycation end products (AGEs) dysregulate adipokines and induce inflammation by binding to their adipocyte receptor (RAGE). Soluble RAGE (sRAGE) prevents AGEs/RAGE signaling. We performed a nested case–control study of the association between sRAGE, adipokines, and incident pancreatic cancer risk in the prospective Women's Health Initiative Study. We individually matched controls (n = 802) to cases (n = 472) on age, race, and blood draw date. We evaluated serum concentrations of sRAGE, adiponectin, leptin, monocyte chemotactic protein 1 (MCP1), and plasminogen activator inhibitor‐1 (PAI1) using immunoassay. We used conditional logistic regression model to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for pancreatic cancer over biomarker quartiles (Q1–Q4). We used principal component analysis to create two composite biomarkers and performed a confirmatory factor analysis to examine the association between composite biomarker scores (CBS) and pancreatic cancer risk. Baseline serum sRAGE concentrations were inversely associated with pancreatic cancer risk (aOR(Q4 vs. Q1 )= 0.70, 95% CI: 0.50–0.99). High MCP1 (aOR (Q4 vs. Q1 )= 2.55, 95% CI: 1.41–4.61) and the higher CBS including MCP1, PAI1, and leptin (aOR(Q4 vs. Q1 )= 1.82, 95% CI = 1.04–3.18) were also associated with increased pancreatic cancer risk among women with BMI <25 kg/m(2) (P values for interaction <0.05). We found an inverse association between prediagnostic sRAGE concentrations and risk of incident pancreatic cancer in postmenopausal women. A proinflammatory CBS was associated with increased risk only in women with normal BMI. MCP1 was not modulated by sRAGE. John Wiley and Sons Inc. 2018-03-23 /pmc/articles/PMC5943487/ /pubmed/29573228 http://dx.doi.org/10.1002/cam4.1426 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
White, Donna L.
Hoogeveen, Ron C.
Chen, Liang
Richardson, Peter
Ravishankar, Milan
Shah, Preksha
Tinker, Lesley
Rohan, Thomas
Whitsel, Eric A.
El‐Serag, Hashem B.
Jiao, Li
A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women
title A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women
title_full A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women
title_fullStr A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women
title_full_unstemmed A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women
title_short A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women
title_sort prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943487/
https://www.ncbi.nlm.nih.gov/pubmed/29573228
http://dx.doi.org/10.1002/cam4.1426
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