Cargando…

The Cytotoxic Effects of Betulin-Conjugated Gold Nanoparticles as Stable Formulations in Normal and Melanoma Cells

Gold nanoparticles are currently investigated as theranostics tools in cancer therapy due to their proper biocompatibility and increased efficacy related to the ease to customize the surface properties and to conjugate other molecules. Betulin, [lup-20(29)-ene-3β, 28-diol], is a pentacyclic triterpe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mioc, Marius, Pavel, Ioana Zinuca, Ghiulai, Roxana, Coricovac, Dorina E., Farcaş, Claudia, Mihali, Ciprian-Valentin, Oprean, Camelia, Serafim, Vlad, Popovici, Ramona A., Dehelean, Cristina A., Shtilman, Michael I., Tsatsakis, Aristidis M., Şoica, Codruţa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943567/ https://www.ncbi.nlm.nih.gov/pubmed/29773989 http://dx.doi.org/10.3389/fphar.2018.00429

Ejemplares similares

Thermosensitive Betulinic Acid-Loaded Magnetoliposomes: A Promising Antitumor Potential for Highly Aggressive Human Breast Adenocarcinoma Cells Under Hyperthermic Conditions
por: Farcas, Claudia Geanina, et al.
Publicado: (2020)

Structural Investigation of Betulinic Acid Plasma Metabolites by Tandem Mass Spectrometry
por: Ghiulai, Roxana, et al.
Publicado: (2022)

Lemon Balm Extracts Prevent Breast Cancer Progression In Vitro and In Ovo on Chorioallantoic Membrane Assay
por: Ghiulai, Roxana, et al.
Publicado: (2020)

Cocrystal Formation of Betulinic Acid and Ascorbic Acid: Synthesis, Physico-Chemical Assessment, Antioxidant, and Antiproliferative Activity
por: Nicolov, Mirela, et al.
Publicado: (2019)

Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer
por: Mioc, Marius, et al.
Publicado: (2018)

Mechanistic investigations of antitumor activity of a Rhodamine B-oleanolic acid derivative bioconjugate
por: Macașoi, Ioana, et al.
Publicado: (2020)

Mechanistic investigations of antitumor activity of a Rhodamine B-oleanolic acid derivative bioconjugate
por: Macașoi, Ioana, et al.
Publicado: (2021)

The Anti-Melanoma Effect of Betulinic Acid Functionalized Gold Nanoparticles: A Mechanistic In Vitro Approach
por: Ghiulai, Roxana, et al.
Publicado: (2022)

The C30-Modulation of Betulinic Acid Using 1,2,4-Triazole: A Promising Strategy for Increasing Its Antimelanoma Cytotoxic Potential
por: Nistor, Gabriela, et al.
Publicado: (2022)

SARS-CoV-2: Repurposed Drugs and Novel Therapeutic Approaches—Insights into Chemical Structure—Biological Activity and Toxicological Screening
por: Dehelean, Cristina Adriana, et al.
Publicado: (2020)

Silver Nanocolloids Loaded with Betulinic Acid with Enhanced Antitumor Potential: Physicochemical Characterization and In Vitro Evaluation
por: Pinzaru, Iulia, et al.
Publicado: (2021)

Standardization of A375 human melanoma models on chicken embryo chorioallantoic membrane and Balb/c nude mice
por: Avram, Stefana, et al.
Publicado: (2017)

Biocompatible Colloidal Suspensions Based on Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Toxicological Profile
por: Coricovac, Dorina-Elena, et al.
Publicado: (2017)

Assessment of Betulinic Acid Cytotoxicity and Mitochondrial Metabolism Impairment in a Human Melanoma Cell Line
por: Coricovac, Dorina, et al.
Publicado: (2021)

Design, synthesis and pharmaco-toxicological assessment of 5-mercapto-1,2,4-triazole derivatives with antibacterial and antiproliferative activity
por: Mioc, Marius, et al.
Publicado: (2017)

Melissa officinalis L. Aqueous Extract Exerts Antioxidant and Antiangiogenic Effects and Improves Physiological Skin Parameters
por: Sipos, Simona, et al.
Publicado: (2021)

The Antimelanoma Biological Assessment of Triterpenic Acid Functionalized Gold Nanoparticles
por: Mioc, Marius, et al.
Publicado: (2023)

A Study on the Behavior of a Polyurethane Drug Carrier in Various pH Media
por: Borcan, Florin, et al.
Publicado: (2020)

Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity
por: Racoviceanu, Roxana, et al.
Publicado: (2020)

Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy
por: Dehelean, Cristina Adriana, et al.
Publicado: (2021)

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents
por: Şoica, Codruţa, et al.
Publicado: (2021)

Novel Triterpenic Acid—Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents
por: Mioc, Marius, et al.
Publicado: (2022)

Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches
por: Ghiulai, Roxana, et al.
Publicado: (2020)

The Synergistic Biologic Activity of Oleanolic and Ursolic Acids in Complex with Hydroxypropyl-γ-Cyclodextrin
por: Soica, Codruţa, et al.
Publicado: (2014)

Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity—A Pharmaco-Toxicological Screening
por: Pancu, Daniel Florin, et al.
Publicado: (2021)

In Vitro Assessment of the Cytotoxic and Antiproliferative Profile of Natural Preparations Containing Bergamot, Orange and Clove Essential Oils
por: Alexa, Vlad Tiberiu, et al.
Publicado: (2022)

The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges
por: Milan, Andreea, et al.
Publicado: (2022)

The Role of Cyclodextrins in the Design and Development of Triterpene-Based Therapeutic Agents
por: Prodea, Alexandra, et al.
Publicado: (2022)

Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II)
por: Mioc, Marius, et al.
Publicado: (2022)

Newly Synthesized CoFe(2−x)Dy(x)O(4) (x = 0; 0.1; 0.2; 0.4) Nanoparticles Reveal Promising Anticancer Activity against Melanoma (A375) and Breast Cancer (MCF-7) Cells
por: Rotunjanu, Slaviţa, et al.
Publicado: (2023)

Ethinylestradiol and Levonorgestrel as Active Agents in Normal Skin, and Pathological Conditions Induced by UVB Exposure: In Vitro and In Ovo Assessments
por: Coricovac, Dorina, et al.
Publicado: (2018)

Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I)
por: Mioc, Marius, et al.
Publicado: (2022)

A Comprehensive Assessment of Apigenin as an Antiproliferative, Proapoptotic, Antiangiogenic and Immunomodulatory Phytocompound
por: Ghițu, Alexandra, et al.
Publicado: (2019)

Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells
por: Soica, Codruta, et al.
Publicado: (2014)

Semisynthetic Derivatives of Pentacyclic Triterpenes Bearing Heterocyclic Moieties with Therapeutic Potential
por: Nistor, Gabriela, et al.
Publicado: (2022)

Fe(3)O(4)@C Matrix with Tailorable Adsorption Capacities for Paracetamol and Acetylsalicylic Acid: Synthesis, Characterization, and Kinetic Modeling
por: Moacă, Elena-Alina, et al.
Publicado: (2019)

Germinated and Ungerminated Seeds Extract from Two Lupinus Species: Biological Compounds Characterization and In Vitro and In Vivo Evaluations
por: Andor, Bogdan, et al.
Publicado: (2016)

Betulin Complex in γ-Cyclodextrin Derivatives: Properties and Antineoplasic Activities in In Vitro and In Vivo Tumor Models
por: Şoica, Codruta, et al.
Publicado: (2012)

Design and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of Acyclovir
por: Borcan, Florin, et al.
Publicado: (2020)

Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation
por: Dehelean, Cristina A, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_u99ce41gbp0cmr0rdum9i99v0a