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Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21
Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potenti...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943590/ https://www.ncbi.nlm.nih.gov/pubmed/29743610 http://dx.doi.org/10.1038/s41598-018-24580-z |
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| author | Ostrom, Quinn T. Kinnersley, Ben Wrensch, Margaret R. Eckel-Passow, Jeanette E. Armstrong, Georgina Rice, Terri Chen, Yanwen Wiencke, John K. McCoy, Lucie S. Hansen, Helen M. Amos, Christopher I. Bernstein, Jonine L. Claus, Elizabeth B. Il’yasova, Dora Johansen, Christoffer Lachance, Daniel H. Lai, Rose K. Merrell, Ryan T. Olson, Sara H. Sadetzki, Siegal Schildkraut, Joellen M. Shete, Sanjay Rubin, Joshua B. Lathia, Justin D. Berens, Michael E. Andersson, Ulrika Rajaraman, Preetha Chanock, Stephen J. Linet, Martha S. Wang, Zhaoming Yeager, Meredith Houlston, Richard S. Jenkins, Robert B. Melin, Beatrice Bondy, Melissa L. Barnholtz-Sloan, Jill. S. |
| author_facet | Ostrom, Quinn T. Kinnersley, Ben Wrensch, Margaret R. Eckel-Passow, Jeanette E. Armstrong, Georgina Rice, Terri Chen, Yanwen Wiencke, John K. McCoy, Lucie S. Hansen, Helen M. Amos, Christopher I. Bernstein, Jonine L. Claus, Elizabeth B. Il’yasova, Dora Johansen, Christoffer Lachance, Daniel H. Lai, Rose K. Merrell, Ryan T. Olson, Sara H. Sadetzki, Siegal Schildkraut, Joellen M. Shete, Sanjay Rubin, Joshua B. Lathia, Justin D. Berens, Michael E. Andersson, Ulrika Rajaraman, Preetha Chanock, Stephen J. Linet, Martha S. Wang, Zhaoming Yeager, Meredith Houlston, Richard S. Jenkins, Robert B. Melin, Beatrice Bondy, Melissa L. Barnholtz-Sloan, Jill. S. |
| author_sort | Ostrom, Quinn T. |
| collection | PubMed |
| description | Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex. |
| format | Online Article Text |
| id | pubmed-5943590 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59435902018-05-14 Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21 Ostrom, Quinn T. Kinnersley, Ben Wrensch, Margaret R. Eckel-Passow, Jeanette E. Armstrong, Georgina Rice, Terri Chen, Yanwen Wiencke, John K. McCoy, Lucie S. Hansen, Helen M. Amos, Christopher I. Bernstein, Jonine L. Claus, Elizabeth B. Il’yasova, Dora Johansen, Christoffer Lachance, Daniel H. Lai, Rose K. Merrell, Ryan T. Olson, Sara H. Sadetzki, Siegal Schildkraut, Joellen M. Shete, Sanjay Rubin, Joshua B. Lathia, Justin D. Berens, Michael E. Andersson, Ulrika Rajaraman, Preetha Chanock, Stephen J. Linet, Martha S. Wang, Zhaoming Yeager, Meredith Houlston, Richard S. Jenkins, Robert B. Melin, Beatrice Bondy, Melissa L. Barnholtz-Sloan, Jill. S. Sci Rep Article Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex. Nature Publishing Group UK 2018-05-09 /pmc/articles/PMC5943590/ /pubmed/29743610 http://dx.doi.org/10.1038/s41598-018-24580-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Ostrom, Quinn T. Kinnersley, Ben Wrensch, Margaret R. Eckel-Passow, Jeanette E. Armstrong, Georgina Rice, Terri Chen, Yanwen Wiencke, John K. McCoy, Lucie S. Hansen, Helen M. Amos, Christopher I. Bernstein, Jonine L. Claus, Elizabeth B. Il’yasova, Dora Johansen, Christoffer Lachance, Daniel H. Lai, Rose K. Merrell, Ryan T. Olson, Sara H. Sadetzki, Siegal Schildkraut, Joellen M. Shete, Sanjay Rubin, Joshua B. Lathia, Justin D. Berens, Michael E. Andersson, Ulrika Rajaraman, Preetha Chanock, Stephen J. Linet, Martha S. Wang, Zhaoming Yeager, Meredith Houlston, Richard S. Jenkins, Robert B. Melin, Beatrice Bondy, Melissa L. Barnholtz-Sloan, Jill. S. Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21 |
| title | Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21 |
| title_full | Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21 |
| title_fullStr | Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21 |
| title_full_unstemmed | Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21 |
| title_short | Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21 |
| title_sort | sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21 |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943590/ https://www.ncbi.nlm.nih.gov/pubmed/29743610 http://dx.doi.org/10.1038/s41598-018-24580-z |
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