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Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area

BACKGROUND/AIMS: Maternal thyroid dysfunction has been associated with adverse pregnancy outcomes. The purpose of our study was to establish trimester-specific reference intervals for thyroid hormones in pregnant women in Korea, where iodine intake is more than adequate and to examine pregnancy and...

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Autores principales: Kim, Hye Jeong, Cho, Yoon Young, Kim, Sun Wook, Kim, Tae Hyuk, Jang, Hye Won, Lee, Soo-Youn, Choi, Suk-Joo, Roh, Cheong-Rae, Kim, Jong-Hwa, Chung, Jae Hoon, Oh, Soo-young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943647/
https://www.ncbi.nlm.nih.gov/pubmed/28171716
http://dx.doi.org/10.3904/kjim.2016.051
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author Kim, Hye Jeong
Cho, Yoon Young
Kim, Sun Wook
Kim, Tae Hyuk
Jang, Hye Won
Lee, Soo-Youn
Choi, Suk-Joo
Roh, Cheong-Rae
Kim, Jong-Hwa
Chung, Jae Hoon
Oh, Soo-young
author_facet Kim, Hye Jeong
Cho, Yoon Young
Kim, Sun Wook
Kim, Tae Hyuk
Jang, Hye Won
Lee, Soo-Youn
Choi, Suk-Joo
Roh, Cheong-Rae
Kim, Jong-Hwa
Chung, Jae Hoon
Oh, Soo-young
author_sort Kim, Hye Jeong
collection PubMed
description BACKGROUND/AIMS: Maternal thyroid dysfunction has been associated with adverse pregnancy outcomes. The purpose of our study was to establish trimester-specific reference intervals for thyroid hormones in pregnant women in Korea, where iodine intake is more than adequate and to examine pregnancy and perinatal outcomes in their offspring. METHODS: Among 459 healthy pregnant women who were screened, we enrolled 417 subjects who had negative results for thyroid autoantibodies. Serum thyroid stimulating hormone (TSH) and free thyroxine were measured using an immunoradiometric assay. Urine iodine concentration was measured using inductively coupled plasma-mass spectrometry in 275 women. Reference ranges of thyroid hormones were determined according to the guidelines of the National Academy of Clinical Biochemistry. Pregnancy and perinatal outcomes were compared according to maternal thyroid function. RESULTS: The reference ranges of serum TSH were 0.03 to 4.24 mIU/L in the first trimester, 0.13 to 4.84 mIU/L in the second trimester, and 0.30 to 5.57 mIU/L in the third trimester. Pregnancy and perinatal outcomes did not vary in mothers with subtle changes in thyroid function. CONCLUSIONS: Trimester-specific thyroid hormone reference intervals in Korean pregnant women differ from those of other countries with different iodine nutrition status and ethnicity. The establishment of population-based, reliable trimester-specific reference intervals is critical for the interpretation of thyroid function in pregnant women to avoid unnecessary tests and treatments.
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spelling pubmed-59436472018-05-16 Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area Kim, Hye Jeong Cho, Yoon Young Kim, Sun Wook Kim, Tae Hyuk Jang, Hye Won Lee, Soo-Youn Choi, Suk-Joo Roh, Cheong-Rae Kim, Jong-Hwa Chung, Jae Hoon Oh, Soo-young Korean J Intern Med Original Article BACKGROUND/AIMS: Maternal thyroid dysfunction has been associated with adverse pregnancy outcomes. The purpose of our study was to establish trimester-specific reference intervals for thyroid hormones in pregnant women in Korea, where iodine intake is more than adequate and to examine pregnancy and perinatal outcomes in their offspring. METHODS: Among 459 healthy pregnant women who were screened, we enrolled 417 subjects who had negative results for thyroid autoantibodies. Serum thyroid stimulating hormone (TSH) and free thyroxine were measured using an immunoradiometric assay. Urine iodine concentration was measured using inductively coupled plasma-mass spectrometry in 275 women. Reference ranges of thyroid hormones were determined according to the guidelines of the National Academy of Clinical Biochemistry. Pregnancy and perinatal outcomes were compared according to maternal thyroid function. RESULTS: The reference ranges of serum TSH were 0.03 to 4.24 mIU/L in the first trimester, 0.13 to 4.84 mIU/L in the second trimester, and 0.30 to 5.57 mIU/L in the third trimester. Pregnancy and perinatal outcomes did not vary in mothers with subtle changes in thyroid function. CONCLUSIONS: Trimester-specific thyroid hormone reference intervals in Korean pregnant women differ from those of other countries with different iodine nutrition status and ethnicity. The establishment of population-based, reliable trimester-specific reference intervals is critical for the interpretation of thyroid function in pregnant women to avoid unnecessary tests and treatments. The Korean Association of Internal Medicine 2018-05 2017-02-08 /pmc/articles/PMC5943647/ /pubmed/28171716 http://dx.doi.org/10.3904/kjim.2016.051 Text en Copyright © 2018 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Hye Jeong
Cho, Yoon Young
Kim, Sun Wook
Kim, Tae Hyuk
Jang, Hye Won
Lee, Soo-Youn
Choi, Suk-Joo
Roh, Cheong-Rae
Kim, Jong-Hwa
Chung, Jae Hoon
Oh, Soo-young
Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area
title Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area
title_full Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area
title_fullStr Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area
title_full_unstemmed Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area
title_short Reference intervals of thyroid hormones during pregnancy in Korea, an iodine-replete area
title_sort reference intervals of thyroid hormones during pregnancy in korea, an iodine-replete area
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943647/
https://www.ncbi.nlm.nih.gov/pubmed/28171716
http://dx.doi.org/10.3904/kjim.2016.051
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