Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection

Iron is an essential factor for the growth and virulence of Mycobacterium tuberculosis (Mtb). However, little is known about the mechanisms by which the host controls iron availability during infection. Since ferritin heavy chain (FtH) is a major intracellular source of reserve iron in the host, we...

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Detalles Bibliográficos
Autores principales: Reddy, Vineel P., Chinta, Krishna C., Saini, Vikram, Glasgow, Joel N., Hull, Travis D., Traylor, Amie, Rey-Stolle, Fernanda, Soares, Miguel P., Madansein, Rajhmun, Rahman, Md Aejazur, Barbas, Coral, Nargan, Kievershen, Naidoo, Threnesan, Ramdial, Pratistadevi K., George, James F., Agarwal, Anupam, Steyn, Adrie J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943674/
https://www.ncbi.nlm.nih.gov/pubmed/29774023
http://dx.doi.org/10.3389/fimmu.2018.00860

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