Cargando…

Human iNPC therapy leads to improvement in functional neurologic outcomes in a pig ischemic stroke model

INTRODUCTION: Stroke is the leading cause of disability in the United States but current therapies are limited with no regenerative potential. Previous translational failures have highlighted the need for large animal models of ischemic stroke and for improved assessments of functional outcomes. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lau, Vivian W., Platt, Simon R., Grace, Harrison E., Baker, Emily W., West, Franklin D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943801/ https://www.ncbi.nlm.nih.gov/pubmed/29761021 http://dx.doi.org/10.1002/brb3.972

Ejemplares similares

Induced Pluripotent Stem Cell-Derived Neural Stem Cell Therapy Enhances Recovery in an Ischemic Stroke Pig Model
por: Baker, Emily W., et al.
Publicado: (2017)

8th International Nuclear Physics Conference : INPC '95
Publicado: (1995)

28th International Nuclear Physics Conference (INPC 2022)
Publicado: (2022)

Neural stem cell therapy for stroke: A multimechanistic approach to restoring neurological function
por: Baker, Emily W., et al.
Publicado: (2019)

Dynamic Changes in the Gut Microbiome at the Acute Stage of Ischemic Stroke in a Pig Model
por: Jeon, Julie, et al.
Publicado: (2020)

Development and characterization of a Yucatan miniature biomedical pig permanent middle cerebral artery occlusion stroke model
por: Platt, Simon R, et al.
Publicado: (2014)

The NPC, in detail
por: Robinson, Richard
Publicado: (2007)

NPC1 plays a role in the trafficking of specific cargo to melanosomes
por: Rus, Alina Adriana, et al.
Publicado: (2023)

Large animal ischemic stroke models: replicating human stroke pathophysiology
por: Kaiser, Erin E., et al.
Publicado: (2020)

Tanshinone IIA-Loaded Nanoparticle and Neural Stem Cell Therapy Enhances Recovery in a Pig Ischemic Stroke Model
por: Kaiser, Erin E, et al.
Publicado: (2022)

Identification and Classification of Rare Variants in NPC1 and NPC2 in Quebec
por: Touma, Lahoud, et al.
Publicado: (2021)

Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor
por: Krishnan, Anuja, et al.
Publicado: (2012)

The pig as a preclinical traumatic brain injury model: current models, functional outcome measures, and translational detection strategies
por: Kinder, Holly A., et al.
Publicado: (2019)

Building and breaking the NPC
por: LeBrasseur, Nicole
Publicado: (2003)

Magnetic Resonance Imaging and Gait Analysis Indicate Similar Outcomes Between Yucatan and Landrace Porcine Ischemic Stroke Models
por: Sneed, Sydney E., et al.
Publicado: (2021)

Tanshinone IIA and Neural Stem Cell Combination Therapy Decreases Gut Inflammation and Maintains Gut Integrity in a Translational Pig Ischemic Stroke Model
por: Jeon, Julie, et al.
Publicado: (2022)

Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke
por: Waters, Elizabeth S., et al.
Publicado: (2021)

Neurological outcome after arterial ischemic stroke in children
por: Nasiri, Jafar, et al.
Publicado: (2016)

npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease
por: Wiweger, Malgorzata, et al.
Publicado: (2021)

Going their own way in the NPC
por: Leslie, Mitch
Publicado: (2007)

Imaging Ischemic and Hemorrhagic Disease of the Brain in Dogs
por: Arnold, Susan A., et al.
Publicado: (2020)

Simulations of NPC1(NTD):NPC2 Protein Complex Reveal Cholesterol Transfer Pathways
por: Hodošček, Milan, et al.
Publicado: (2018)

NPC 15669 blocks neutrophil CD18 increase and lung injury during cardiopulmonary bypass in pigs
por: Bator, J. M., et al.
Publicado: (1993)

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress
por: Höglinger, D., et al.
Publicado: (2019)

Tanshinone IIA-loaded nanoparticles and neural stem cell combination therapy improves gut homeostasis and recovery in a pig ischemic stroke model
por: Jeon, Julie H., et al.
Publicado: (2023)

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins
por: Saha, Piyali, et al.
Publicado: (2020)

An integrative multivariate approach for predicting functional recovery using magnetic resonance imaging parameters in a translational pig ischemic stroke model
por: Kaiser, Erin E., et al.
Publicado: (2020)

Hereditary protein S deficiency leads to ischemic stroke
por: WANG, ZHAO-HUI, et al.
Publicado: (2015)

RNA Export through the NPC in Eukaryotes
por: Okamura, Masumi, et al.
Publicado: (2015)

OVOL2 in metastasis prevention in NPC
por: Song, Kyung-A, et al.
Publicado: (2018)

Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions
por: Zhao, Yuguang, et al.
Publicado: (2016)

Exploring the predictive value of lesion topology on motor function outcomes in a porcine ischemic stroke model
por: Scheulin, Kelly M., et al.
Publicado: (2021)

The effect of material assignment in nasal cavity on dose calculation for nasopharyngeal carcinoma (NPC) using Acuros XB
por: Cheung, Michael L. M., et al.
Publicado: (2022)

Hyperintense vessels on imaging account for neurological function independent of lesion volume in acute ischemic stroke
por: Bunker, Lisa D., et al.
Publicado: (2022)

Pre-stroke glycemic control is associated with early neurologic deterioration in acute atrial fibrillation-related ischemic stroke
por: Kim, J.-S., et al.
Publicado: (2017)

Mitochondrial DNA haplogroups and short-term neurological outcomes of ischemic stroke
por: Cai, Biyang, et al.
Publicado: (2015)

Regulation of Neurological Devices and Neurointerventional Endovascular Approaches for Acute Ischemic Stroke
por: Loftus, Christopher M., et al.
Publicado: (2018)

Improvement of Neurological Function in Rats with Ischemic Stroke by Adipose-derived Pericytes
por: Ogay, Vyacheslav, et al.
Publicado: (2020)

Cardiac Stroke Volume Index Is Associated With Early Neurological Improvement in Acute Ischemic Stroke Patients
por: Miller, Joseph, et al.
Publicado: (2021)

Pre-Stroke Statin Use Is Associated with Mild Neurological Deficits at the Onset of Acute Ischemic Stroke
por: Mori, Takahisa, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j1922is78ra9d6kc1ade151e5n