The radiosensitive effect of apatinib for hepatocellular carcinoma patient with big paraspinal metastasis: A case report

RATIONALE: Hepatocellular carcinoma (HCC) is a highly invasive cancer associated with great mortality rates. The prognosis of advanced HCC is very poor. PATIENT CONCERNS: Here, we report a HCC patient with a big paraspinal metastasis with 10 cm in diameter who failed the treatment of sorafenib. DIAG...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Hong, Zhao, Yaqin, Wang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943896/
https://www.ncbi.nlm.nih.gov/pubmed/29480860
http://dx.doi.org/10.1097/MD.0000000000009598
_version_ 1783321719629414400
author Zhu, Hong
Zhao, Yaqin
Wang, Xin
author_facet Zhu, Hong
Zhao, Yaqin
Wang, Xin
author_sort Zhu, Hong
collection PubMed
description RATIONALE: Hepatocellular carcinoma (HCC) is a highly invasive cancer associated with great mortality rates. The prognosis of advanced HCC is very poor. PATIENT CONCERNS: Here, we report a HCC patient with a big paraspinal metastasis with 10 cm in diameter who failed the treatment of sorafenib. DIAGNOSES: Sorafenib refractory HCC with big paraspinal metastasis. INTERVENTIONS: The concurrent treatment of apatinib with stereotactic body radiotherapy (SBRT). OUTCOMES: The paraspinal metastasis with 10 cm in diameter showed nearly complete response. LESSONS: We think that the apatinib may be a good choice for HCC and it may function as a radiosensitizer of HCC. However, it warrants further investigation in the future prospective clinical studies.
format Online
Article
Text
id pubmed-5943896
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-59438962018-05-15 The radiosensitive effect of apatinib for hepatocellular carcinoma patient with big paraspinal metastasis: A case report Zhu, Hong Zhao, Yaqin Wang, Xin Medicine (Baltimore) Research Article RATIONALE: Hepatocellular carcinoma (HCC) is a highly invasive cancer associated with great mortality rates. The prognosis of advanced HCC is very poor. PATIENT CONCERNS: Here, we report a HCC patient with a big paraspinal metastasis with 10 cm in diameter who failed the treatment of sorafenib. DIAGNOSES: Sorafenib refractory HCC with big paraspinal metastasis. INTERVENTIONS: The concurrent treatment of apatinib with stereotactic body radiotherapy (SBRT). OUTCOMES: The paraspinal metastasis with 10 cm in diameter showed nearly complete response. LESSONS: We think that the apatinib may be a good choice for HCC and it may function as a radiosensitizer of HCC. However, it warrants further investigation in the future prospective clinical studies. Wolters Kluwer Health 2018-01-12 /pmc/articles/PMC5943896/ /pubmed/29480860 http://dx.doi.org/10.1097/MD.0000000000009598 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Zhu, Hong
Zhao, Yaqin
Wang, Xin
The radiosensitive effect of apatinib for hepatocellular carcinoma patient with big paraspinal metastasis: A case report
title The radiosensitive effect of apatinib for hepatocellular carcinoma patient with big paraspinal metastasis: A case report
title_full The radiosensitive effect of apatinib for hepatocellular carcinoma patient with big paraspinal metastasis: A case report
title_fullStr The radiosensitive effect of apatinib for hepatocellular carcinoma patient with big paraspinal metastasis: A case report
title_full_unstemmed The radiosensitive effect of apatinib for hepatocellular carcinoma patient with big paraspinal metastasis: A case report
title_short The radiosensitive effect of apatinib for hepatocellular carcinoma patient with big paraspinal metastasis: A case report
title_sort radiosensitive effect of apatinib for hepatocellular carcinoma patient with big paraspinal metastasis: a case report
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943896/
https://www.ncbi.nlm.nih.gov/pubmed/29480860
http://dx.doi.org/10.1097/MD.0000000000009598
work_keys_str_mv AT zhuhong theradiosensitiveeffectofapatinibforhepatocellularcarcinomapatientwithbigparaspinalmetastasisacasereport
AT zhaoyaqin theradiosensitiveeffectofapatinibforhepatocellularcarcinomapatientwithbigparaspinalmetastasisacasereport
AT wangxin theradiosensitiveeffectofapatinibforhepatocellularcarcinomapatientwithbigparaspinalmetastasisacasereport
AT zhuhong radiosensitiveeffectofapatinibforhepatocellularcarcinomapatientwithbigparaspinalmetastasisacasereport
AT zhaoyaqin radiosensitiveeffectofapatinibforhepatocellularcarcinomapatientwithbigparaspinalmetastasisacasereport
AT wangxin radiosensitiveeffectofapatinibforhepatocellularcarcinomapatientwithbigparaspinalmetastasisacasereport

Ejemplares similares