Design and Discovery of Quinazoline- and Thiourea-Containing Sorafenib Analogs as EGFR and VEGFR-2 Dual TK Inhibitors

Both EGFR and VEGFR-2 play a critical role in tumor growth, angiogenesis and metastasis, and targeting EGFR and VEGFR-2 simultaneously represents a promising approach to cancer treatment. In this work, a series of novel quinazoline- and thiourea-containing sorafenib analogs (10a–v) were designed and...

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Detalles Bibliográficos
Autores principales: Sun, Shaofeng, Zhang, Jingwen, Wang, Ningning, Kong, Xiangkai, Fu, Fenghua, Wang, Hongbo, Yao, Jianwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943947/
https://www.ncbi.nlm.nih.gov/pubmed/29295519
http://dx.doi.org/10.3390/molecules23010024

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