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Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study

BACKGROUND: The inter-relationships of atrial fibrillation (AF) to retinal vascular occlusions (whether retinal artery occlusion (RAO) or retinal venous occlusion (RVO)) remain unclear. It is unknown if a presentation of retinal artery or venous occlusions may indicate a new onset cardiac arrhythmia...

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Autores principales: Christiansen, Christine Benn, Torp-Pedersen, Christian, Olesen, Jonas Bjerring, Gislason, Gunnar, Lamberts, Morten, Carlson, Nicholas, Buron, Mathias, Juul, Nikolai, Lip, Gregory Y. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944106/
https://www.ncbi.nlm.nih.gov/pubmed/29743025
http://dx.doi.org/10.1186/s12872-018-0825-1
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author Christiansen, Christine Benn
Torp-Pedersen, Christian
Olesen, Jonas Bjerring
Gislason, Gunnar
Lamberts, Morten
Carlson, Nicholas
Buron, Mathias
Juul, Nikolai
Lip, Gregory Y. H.
author_facet Christiansen, Christine Benn
Torp-Pedersen, Christian
Olesen, Jonas Bjerring
Gislason, Gunnar
Lamberts, Morten
Carlson, Nicholas
Buron, Mathias
Juul, Nikolai
Lip, Gregory Y. H.
author_sort Christiansen, Christine Benn
collection PubMed
description BACKGROUND: The inter-relationships of atrial fibrillation (AF) to retinal vascular occlusions (whether retinal artery occlusion (RAO) or retinal venous occlusion (RVO)) remain unclear. It is unknown if a presentation of retinal artery or venous occlusions may indicate a new onset cardiac arrhythmia. To shed light on this association, we investigated the risk of new onset AF in patients with known RAO and RVO. METHODS: Patients with retinal occlusions from 1997 to 2011 were identified through Danish nationwide registries and matched 1:5 according to sex and age. Cumulative incidence and unadjusted rates of AF according to retinal vascular occlusions (i.e. RAO or RVO) were determined. Hazard ratios (HR) of AF according to retinal vascular occlusion were adjusted for hypertension, diabetes, vascular disease and prior stroke/systemic thromboembolism/transient ischemic attack. RESULTS: One thousand three hundred sixty-eight cases with retinal vascular occlusions were identified (median age 71.4 (inter quartile range (IQR); 61.2–79.8), 47.3% male). RAO constituted 706 cases (51.6%) and RVO 529 (38.7%). The rate of incident AF amongst all cases with retinal vascular occlusion was 1.74 per 100 person-years (95% confidence interval (CI), 1.47–2.06) compared to 1.22 (95% CI, 1.12–1.33) in the matched control group. The rate of AF in RAO was 2.01 (95% CI, 1.6–2.52) and 1.52 (1.15–2.01) in RVO. HRs of incident AF adjusted for cardiovascular comorbidities were 1.26 (95% CI; 1.04–1.53, p = 0.019) for any retinal vascular occlusion, 1.45 (95% CI; 1.10–1.89, p = 0.015) for RAO, and 1.02 (95% CI; 0.74–1.39, p = 0.920) for RVO. CONCLUSIONS: A new diagnosis of retinal vascular occlusion in patients without prior AF was associated with increased risk of incident AF, particularly amongst patients with RAO. Awareness of AF in patients with retinal vascular occlusions is advised.
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spelling pubmed-59441062018-05-14 Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study Christiansen, Christine Benn Torp-Pedersen, Christian Olesen, Jonas Bjerring Gislason, Gunnar Lamberts, Morten Carlson, Nicholas Buron, Mathias Juul, Nikolai Lip, Gregory Y. H. BMC Cardiovasc Disord Research Article BACKGROUND: The inter-relationships of atrial fibrillation (AF) to retinal vascular occlusions (whether retinal artery occlusion (RAO) or retinal venous occlusion (RVO)) remain unclear. It is unknown if a presentation of retinal artery or venous occlusions may indicate a new onset cardiac arrhythmia. To shed light on this association, we investigated the risk of new onset AF in patients with known RAO and RVO. METHODS: Patients with retinal occlusions from 1997 to 2011 were identified through Danish nationwide registries and matched 1:5 according to sex and age. Cumulative incidence and unadjusted rates of AF according to retinal vascular occlusions (i.e. RAO or RVO) were determined. Hazard ratios (HR) of AF according to retinal vascular occlusion were adjusted for hypertension, diabetes, vascular disease and prior stroke/systemic thromboembolism/transient ischemic attack. RESULTS: One thousand three hundred sixty-eight cases with retinal vascular occlusions were identified (median age 71.4 (inter quartile range (IQR); 61.2–79.8), 47.3% male). RAO constituted 706 cases (51.6%) and RVO 529 (38.7%). The rate of incident AF amongst all cases with retinal vascular occlusion was 1.74 per 100 person-years (95% confidence interval (CI), 1.47–2.06) compared to 1.22 (95% CI, 1.12–1.33) in the matched control group. The rate of AF in RAO was 2.01 (95% CI, 1.6–2.52) and 1.52 (1.15–2.01) in RVO. HRs of incident AF adjusted for cardiovascular comorbidities were 1.26 (95% CI; 1.04–1.53, p = 0.019) for any retinal vascular occlusion, 1.45 (95% CI; 1.10–1.89, p = 0.015) for RAO, and 1.02 (95% CI; 0.74–1.39, p = 0.920) for RVO. CONCLUSIONS: A new diagnosis of retinal vascular occlusion in patients without prior AF was associated with increased risk of incident AF, particularly amongst patients with RAO. Awareness of AF in patients with retinal vascular occlusions is advised. BioMed Central 2018-05-10 /pmc/articles/PMC5944106/ /pubmed/29743025 http://dx.doi.org/10.1186/s12872-018-0825-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Christiansen, Christine Benn
Torp-Pedersen, Christian
Olesen, Jonas Bjerring
Gislason, Gunnar
Lamberts, Morten
Carlson, Nicholas
Buron, Mathias
Juul, Nikolai
Lip, Gregory Y. H.
Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study
title Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study
title_full Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study
title_fullStr Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study
title_full_unstemmed Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study
title_short Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study
title_sort risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944106/
https://www.ncbi.nlm.nih.gov/pubmed/29743025
http://dx.doi.org/10.1186/s12872-018-0825-1
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