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Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study
BACKGROUND: The inter-relationships of atrial fibrillation (AF) to retinal vascular occlusions (whether retinal artery occlusion (RAO) or retinal venous occlusion (RVO)) remain unclear. It is unknown if a presentation of retinal artery or venous occlusions may indicate a new onset cardiac arrhythmia...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944106/ https://www.ncbi.nlm.nih.gov/pubmed/29743025 http://dx.doi.org/10.1186/s12872-018-0825-1 |
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author | Christiansen, Christine Benn Torp-Pedersen, Christian Olesen, Jonas Bjerring Gislason, Gunnar Lamberts, Morten Carlson, Nicholas Buron, Mathias Juul, Nikolai Lip, Gregory Y. H. |
author_facet | Christiansen, Christine Benn Torp-Pedersen, Christian Olesen, Jonas Bjerring Gislason, Gunnar Lamberts, Morten Carlson, Nicholas Buron, Mathias Juul, Nikolai Lip, Gregory Y. H. |
author_sort | Christiansen, Christine Benn |
collection | PubMed |
description | BACKGROUND: The inter-relationships of atrial fibrillation (AF) to retinal vascular occlusions (whether retinal artery occlusion (RAO) or retinal venous occlusion (RVO)) remain unclear. It is unknown if a presentation of retinal artery or venous occlusions may indicate a new onset cardiac arrhythmia. To shed light on this association, we investigated the risk of new onset AF in patients with known RAO and RVO. METHODS: Patients with retinal occlusions from 1997 to 2011 were identified through Danish nationwide registries and matched 1:5 according to sex and age. Cumulative incidence and unadjusted rates of AF according to retinal vascular occlusions (i.e. RAO or RVO) were determined. Hazard ratios (HR) of AF according to retinal vascular occlusion were adjusted for hypertension, diabetes, vascular disease and prior stroke/systemic thromboembolism/transient ischemic attack. RESULTS: One thousand three hundred sixty-eight cases with retinal vascular occlusions were identified (median age 71.4 (inter quartile range (IQR); 61.2–79.8), 47.3% male). RAO constituted 706 cases (51.6%) and RVO 529 (38.7%). The rate of incident AF amongst all cases with retinal vascular occlusion was 1.74 per 100 person-years (95% confidence interval (CI), 1.47–2.06) compared to 1.22 (95% CI, 1.12–1.33) in the matched control group. The rate of AF in RAO was 2.01 (95% CI, 1.6–2.52) and 1.52 (1.15–2.01) in RVO. HRs of incident AF adjusted for cardiovascular comorbidities were 1.26 (95% CI; 1.04–1.53, p = 0.019) for any retinal vascular occlusion, 1.45 (95% CI; 1.10–1.89, p = 0.015) for RAO, and 1.02 (95% CI; 0.74–1.39, p = 0.920) for RVO. CONCLUSIONS: A new diagnosis of retinal vascular occlusion in patients without prior AF was associated with increased risk of incident AF, particularly amongst patients with RAO. Awareness of AF in patients with retinal vascular occlusions is advised. |
format | Online Article Text |
id | pubmed-5944106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-59441062018-05-14 Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study Christiansen, Christine Benn Torp-Pedersen, Christian Olesen, Jonas Bjerring Gislason, Gunnar Lamberts, Morten Carlson, Nicholas Buron, Mathias Juul, Nikolai Lip, Gregory Y. H. BMC Cardiovasc Disord Research Article BACKGROUND: The inter-relationships of atrial fibrillation (AF) to retinal vascular occlusions (whether retinal artery occlusion (RAO) or retinal venous occlusion (RVO)) remain unclear. It is unknown if a presentation of retinal artery or venous occlusions may indicate a new onset cardiac arrhythmia. To shed light on this association, we investigated the risk of new onset AF in patients with known RAO and RVO. METHODS: Patients with retinal occlusions from 1997 to 2011 were identified through Danish nationwide registries and matched 1:5 according to sex and age. Cumulative incidence and unadjusted rates of AF according to retinal vascular occlusions (i.e. RAO or RVO) were determined. Hazard ratios (HR) of AF according to retinal vascular occlusion were adjusted for hypertension, diabetes, vascular disease and prior stroke/systemic thromboembolism/transient ischemic attack. RESULTS: One thousand three hundred sixty-eight cases with retinal vascular occlusions were identified (median age 71.4 (inter quartile range (IQR); 61.2–79.8), 47.3% male). RAO constituted 706 cases (51.6%) and RVO 529 (38.7%). The rate of incident AF amongst all cases with retinal vascular occlusion was 1.74 per 100 person-years (95% confidence interval (CI), 1.47–2.06) compared to 1.22 (95% CI, 1.12–1.33) in the matched control group. The rate of AF in RAO was 2.01 (95% CI, 1.6–2.52) and 1.52 (1.15–2.01) in RVO. HRs of incident AF adjusted for cardiovascular comorbidities were 1.26 (95% CI; 1.04–1.53, p = 0.019) for any retinal vascular occlusion, 1.45 (95% CI; 1.10–1.89, p = 0.015) for RAO, and 1.02 (95% CI; 0.74–1.39, p = 0.920) for RVO. CONCLUSIONS: A new diagnosis of retinal vascular occlusion in patients without prior AF was associated with increased risk of incident AF, particularly amongst patients with RAO. Awareness of AF in patients with retinal vascular occlusions is advised. BioMed Central 2018-05-10 /pmc/articles/PMC5944106/ /pubmed/29743025 http://dx.doi.org/10.1186/s12872-018-0825-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Christiansen, Christine Benn Torp-Pedersen, Christian Olesen, Jonas Bjerring Gislason, Gunnar Lamberts, Morten Carlson, Nicholas Buron, Mathias Juul, Nikolai Lip, Gregory Y. H. Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study |
title | Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study |
title_full | Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study |
title_fullStr | Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study |
title_full_unstemmed | Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study |
title_short | Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study |
title_sort | risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944106/ https://www.ncbi.nlm.nih.gov/pubmed/29743025 http://dx.doi.org/10.1186/s12872-018-0825-1 |
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