Cargando…

Characterization of Site-Specific Phosphorylation of NF-κB p65 in Retinal Cells in Response to High Glucose and Cytokine Polarization

BACKGROUND: Inflammation is an important contributor to the pathogenesis of diabetic retinopathy (DR). NF-κB is a master transcriptional regulator for numerous inflammatory genes. Although NF-κB is comprised of multiple subunits, p65 has received the most attention. However, the p65 subunit can be p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Haoshen, Berger, Elizabeth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944204/ https://www.ncbi.nlm.nih.gov/pubmed/29853786 http://dx.doi.org/10.1155/2018/3020675

Ejemplares similares

Specification of the NF-κB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKKε
por: Moreno, Rita, et al.
Publicado: (2010)

NF-κB activation by Helicobacter pylori requires Akt-mediated phosphorylation of p65
por: Takeshima, Eriko, et al.
Publicado: (2009)

TIPE2 regulates periodontal inflammation by inhibiting NF-κB p65 phosphorylation
por: DU, Yanmei, et al.
Publicado: (2023)

Ubiquitin Specific Protease USP48 Destabilizes NF-κB/p65 in Retinal Pigment Epithelium Cells
por: Mirra, Serena, et al.
Publicado: (2022)

Retraction: NF-κB activation by Helicobacter pylori requires Akt-mediated phosphorylation of p65
por: Takeshima, Eriko, et al.
Publicado: (2011)

Thr(435) phosphorylation regulates RelA (p65) NF-κB subunit transactivation
por: O'Shea, John M., et al.
Publicado: (2010)

Expression of NF-κB p65 phosphorylated at serine-536 in rectal cancer with or without preoperative radiotherapy
por: Lewander, Andreas, et al.
Publicado: (2011)

Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target
por: Xu, Xuan, et al.
Publicado: (2021)

NF-κB p65 directs sex-specific neuroprotection in human neurons
por: Ruiz-Perera, Lucia M., et al.
Publicado: (2018)

DING Protein Inhibits Transcription of HIV-1 Gene through Suppression of Phosphorylation of NF-κB p65
por: Darbinian, Nune, et al.
Publicado: (2020)

Phosphorylation of p65(RelA) on Ser(547) by ATM Represses NF-κB-Dependent Transcription of Specific Genes after Genotoxic Stress
por: Sabatel, Hélène, et al.
Publicado: (2012)

Co‐expression of NF‐κB‐p65 and phosphorylated NF‐κB‐p105 is associated with poor prognosis in surgically resectable non‐small cell lung cancer
por: Lin, Gen, et al.
Publicado: (2018)

Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition
por: Kwon, Hyung-Joon, et al.
Publicado: (2016)

Secretory leucoprotease inhibitor binds to NF-κB binding sites in monocytes and inhibits p65 binding
por: Taggart, Clifford C., et al.
Publicado: (2005)

The Regulation of NF-κB Subunits by Phosphorylation
por: Christian, Frank, et al.
Publicado: (2016)

Cyclin-Dependent Kinase 6 Phosphorylates NF-κB P65 at Serine 536 and Contributes to the Regulation of Inflammatory Gene Expression
por: Buss, Holger, et al.
Publicado: (2012)

Fangchinoline attenuates cardiac dysfunction in rats with endotoxemia via the inhibition of ERK1/2 and NF-κB p65 phosphorylation
por: Chen, Hongwei, et al.
Publicado: (2020)

Platelet membrane-coated alterbrassicene A nanoparticle inhibits calcification of the aortic valve by suppressing phosphorylation P65 NF-κB
por: Geng, Bingchuan, et al.
Publicado: (2023)

Mechanisms of NF-κB p65 and strategies for therapeutic manipulation
por: Giridharan, Sivagami, et al.
Publicado: (2018)

The Expression of SOCS and NF-ϰB p65 in Hypopharyngeal Carcinoma
por: FENG, Shu, et al.
Publicado: (2018)

Identification of an NF-κB p50/p65-responsive site in the human MIR155HG promoter
por: Thompson, Ryan C, et al.
Publicado: (2013)

GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10
por: Abd-Ellah, Ali, et al.
Publicado: (2018)

Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression
por: Riedlinger, Tabea, et al.
Publicado: (2019)

Sodium butyrate inhibits high glucose-induced inflammation by controlling the acetylation of NF-κB p65 in human monocytes
por: Moon, Ha-Rin, et al.
Publicado: (2023)

M-CSF Induces Monocyte Survival by Activating NF-κB p65 Phosphorylation at Ser276 via Protein Kinase C
por: Wang, Yijie, et al.
Publicado: (2011)

The N Terminus of Orf Virus-Encoded Protein 002 Inhibits Acetylation of NF-κB p65 by Preventing Ser(276) Phosphorylation
por: Ning, Zhangyong, et al.
Publicado: (2013)

PAK5-mediated phosphorylation and nuclear translocation of NF-κB-p65 promotes breast cancer cell proliferation in vitro and in vivo
por: Zhang, Ying-Chun, et al.
Publicado: (2017)

Bacterial lipopolysaccharide and antimicrobial LL-37 enhance ICAM-1 expression and NF-κB p65 phosphorylation in senescent endothelial cells
por: Suzuki, Kaori, et al.
Publicado: (2019)

Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-κB and STAT3
por: Sun, Hai-Jian, et al.
Publicado: (2020)

The regulation of sequence specific NF-κB DNA binding and transcription by IKKβ phosphorylation of NF-κB p50 at serine 80
por: Smith, Emma L, et al.
Publicado: (2019)

Epidermal p65/NF-κB signalling is essential for skin carcinogenesis
por: Kim, Chun, et al.
Publicado: (2014)

Serum NF-κBp65, TLR4 as Biomarker for Diagnosis of Preeclampsia
por: Litang, Zhao, et al.
Publicado: (2017)

Peimine Inhibits the Production of Proinflammatory Cytokines Through Regulation of the Phosphorylation of NF-κB and MAPKs in HMC-1 Cells
por: Park, Ji Hye, et al.
Publicado: (2017)

Inhibiting NF-κB Signaling Activation Reduces Retinal Neovascularization by Promoting a Polarization Shift in Macrophages
por: Sui, Ailing, et al.
Publicado: (2020)

Specific NFκB subunit activation and kinetics of cytokine induction in adenoviral keratitis
por: Rajaiya, Jaya, et al.
Publicado: (2009)

PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm
por: Ono, Rumiko, et al.
Publicado: (2015)

Gallic acid inhibits the release of ADAMTS4 in nucleus pulposus cells by inhibiting p65 phosphorylation and acetylation of the NF-κB signaling pathway
por: Huang, Yao, et al.
Publicado: (2017)

Fructose-1, 6-bisphosphatase 1 interacts with NF-κB p65 to regulate breast tumorigenesis via PIM2 induced phosphorylation
por: Lu, Chao, et al.
Publicado: (2020)

Supplemental wheat germ modulates phosphorylation of STAT3 in the gut and NF-κBp65 in the adipose tissue of mice fed a Western diet
por: Ojo, Babajide A., et al.
Publicado: (2022)

The levels of NF-κB p50 and NF-κB p65 play a role in thyroid carcinoma malignancy in vivo
por: Le, Fei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2ettn1pp4p3on932p13sjleco6