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Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms
Oxidative stress is a condition that arises when cells are faced with levels of reactive oxygen species (ROS) that destabilize the homeostatic redox balance. High levels of ROS can cause damage to macromolecules including DNA, lipids, and proteins, eventually resulting in cell death. Moderate levels...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944262/ https://www.ncbi.nlm.nih.gov/pubmed/29854077 http://dx.doi.org/10.1155/2018/2138502 |
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author | Cobbaut, Mathias Van Lint, Johan |
author_facet | Cobbaut, Mathias Van Lint, Johan |
author_sort | Cobbaut, Mathias |
collection | PubMed |
description | Oxidative stress is a condition that arises when cells are faced with levels of reactive oxygen species (ROS) that destabilize the homeostatic redox balance. High levels of ROS can cause damage to macromolecules including DNA, lipids, and proteins, eventually resulting in cell death. Moderate levels of ROS however serve as signaling molecules that can drive and potentiate several cellular phenotypes. Increased levels of ROS are associated with a number of diseases including neurological disorders and cancer. In cancer, increased ROS levels can contribute to cancer cell survival and proliferation via the activation of several signaling pathways. One of the downstream effectors of increased ROS is the protein kinase D (PKD) family of kinases. In this review, we will discuss the regulation and function of this family of ROS-activated kinases and describe their unique isoform-specific features, in terms of both kinase regulation and signaling output. |
format | Online Article Text |
id | pubmed-5944262 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-59442622018-05-31 Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms Cobbaut, Mathias Van Lint, Johan Oxid Med Cell Longev Review Article Oxidative stress is a condition that arises when cells are faced with levels of reactive oxygen species (ROS) that destabilize the homeostatic redox balance. High levels of ROS can cause damage to macromolecules including DNA, lipids, and proteins, eventually resulting in cell death. Moderate levels of ROS however serve as signaling molecules that can drive and potentiate several cellular phenotypes. Increased levels of ROS are associated with a number of diseases including neurological disorders and cancer. In cancer, increased ROS levels can contribute to cancer cell survival and proliferation via the activation of several signaling pathways. One of the downstream effectors of increased ROS is the protein kinase D (PKD) family of kinases. In this review, we will discuss the regulation and function of this family of ROS-activated kinases and describe their unique isoform-specific features, in terms of both kinase regulation and signaling output. Hindawi 2018-04-26 /pmc/articles/PMC5944262/ /pubmed/29854077 http://dx.doi.org/10.1155/2018/2138502 Text en Copyright © 2018 Mathias Cobbaut and Johan Van Lint. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Cobbaut, Mathias Van Lint, Johan Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms |
title | Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms |
title_full | Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms |
title_fullStr | Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms |
title_full_unstemmed | Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms |
title_short | Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms |
title_sort | function and regulation of protein kinase d in oxidative stress: a tale of isoforms |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944262/ https://www.ncbi.nlm.nih.gov/pubmed/29854077 http://dx.doi.org/10.1155/2018/2138502 |
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