Cargando…
Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications
Social cognitive function, involved in the perception, processing, and interpretation of social information, has been shown to be crucial for successful communication and interpersonal relationships, thereby significantly impacting mental health, well-being, and quality of life. In this regard, asse...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944290/ https://www.ncbi.nlm.nih.gov/pubmed/29854017 http://dx.doi.org/10.1155/2018/1849794 |
_version_ | 1783321805486817280 |
---|---|
author | Christidi, Foteini Migliaccio, Raffaella Santamaría-García, Hernando Santangelo, Gabriella Trojsi, Francesca |
author_facet | Christidi, Foteini Migliaccio, Raffaella Santamaría-García, Hernando Santangelo, Gabriella Trojsi, Francesca |
author_sort | Christidi, Foteini |
collection | PubMed |
description | Social cognitive function, involved in the perception, processing, and interpretation of social information, has been shown to be crucial for successful communication and interpersonal relationships, thereby significantly impacting mental health, well-being, and quality of life. In this regard, assessment of social cognition, mainly focusing on four key domains, such as theory of mind (ToM), emotional empathy, and social perception and behavior, has been increasingly evaluated in clinical settings, given the potential implications of impairments of these skills for therapeutic decision-making. With regard to neurodegenerative diseases (NDs), most disorders, characterized by variable disease phenotypes and progression, although similar for the unfavorable prognosis, are associated to impairments of social cognitive function, with consequent negative effects on patients' management. Specifically, in some NDs these deficits may represent core diagnostic criteria, such as for behavioral variant frontotemporal dementia (bvFTD), or may emerge during the disease course as critical aspects, such as for Parkinson's and Alzheimer's diseases. On this background, we aimed to revise the most updated evidence on the neurobiological hypotheses derived from network-based approaches, clinical manifestations, and assessment tools of social cognitive dysfunctions in NDs, also prospecting potential benefits on patients' well-being, quality of life, and outcome derived from potential therapeutic perspectives of these deficits. |
format | Online Article Text |
id | pubmed-5944290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-59442902018-05-31 Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications Christidi, Foteini Migliaccio, Raffaella Santamaría-García, Hernando Santangelo, Gabriella Trojsi, Francesca Behav Neurol Review Article Social cognitive function, involved in the perception, processing, and interpretation of social information, has been shown to be crucial for successful communication and interpersonal relationships, thereby significantly impacting mental health, well-being, and quality of life. In this regard, assessment of social cognition, mainly focusing on four key domains, such as theory of mind (ToM), emotional empathy, and social perception and behavior, has been increasingly evaluated in clinical settings, given the potential implications of impairments of these skills for therapeutic decision-making. With regard to neurodegenerative diseases (NDs), most disorders, characterized by variable disease phenotypes and progression, although similar for the unfavorable prognosis, are associated to impairments of social cognitive function, with consequent negative effects on patients' management. Specifically, in some NDs these deficits may represent core diagnostic criteria, such as for behavioral variant frontotemporal dementia (bvFTD), or may emerge during the disease course as critical aspects, such as for Parkinson's and Alzheimer's diseases. On this background, we aimed to revise the most updated evidence on the neurobiological hypotheses derived from network-based approaches, clinical manifestations, and assessment tools of social cognitive dysfunctions in NDs, also prospecting potential benefits on patients' well-being, quality of life, and outcome derived from potential therapeutic perspectives of these deficits. Hindawi 2018-04-26 /pmc/articles/PMC5944290/ /pubmed/29854017 http://dx.doi.org/10.1155/2018/1849794 Text en Copyright © 2018 Foteini Christidi et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Christidi, Foteini Migliaccio, Raffaella Santamaría-García, Hernando Santangelo, Gabriella Trojsi, Francesca Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications |
title | Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications |
title_full | Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications |
title_fullStr | Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications |
title_full_unstemmed | Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications |
title_short | Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications |
title_sort | social cognition dysfunctions in neurodegenerative diseases: neuroanatomical correlates and clinical implications |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944290/ https://www.ncbi.nlm.nih.gov/pubmed/29854017 http://dx.doi.org/10.1155/2018/1849794 |
work_keys_str_mv | AT christidifoteini socialcognitiondysfunctionsinneurodegenerativediseasesneuroanatomicalcorrelatesandclinicalimplications AT migliaccioraffaella socialcognitiondysfunctionsinneurodegenerativediseasesneuroanatomicalcorrelatesandclinicalimplications AT santamariagarciahernando socialcognitiondysfunctionsinneurodegenerativediseasesneuroanatomicalcorrelatesandclinicalimplications AT santangelogabriella socialcognitiondysfunctionsinneurodegenerativediseasesneuroanatomicalcorrelatesandclinicalimplications AT trojsifrancesca socialcognitiondysfunctionsinneurodegenerativediseasesneuroanatomicalcorrelatesandclinicalimplications |