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NLRP3 Inflammasome and Caspase-1/11 Pathway Orchestrate Different Outcomes in the Host Protection Against Trypanosoma cruzi Acute Infection
Infection with protozoan parasite Trypanosoma cruzi results in activation of nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs). NLR activation leads to inflammasome formation, the activation of caspase-1, and the subsequent cleavage of IL-1β and IL-18. Considering that in...
Autores principales: | Paroli, Augusto F., Gonzalez, Patricia V., Díaz-Luján, Cintia, Onofrio, Luisina I., Arocena, Alfredo, Cano, Roxana C., Carrera-Silva, Eugenio A., Gea, Susana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944318/ https://www.ncbi.nlm.nih.gov/pubmed/29774028 http://dx.doi.org/10.3389/fimmu.2018.00913 |
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