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Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites

INTRODUCTION: The relationship between serum galectin-3 and incident cognitive impairment was analyzed in the Reasons for Geographic and Racial Differences in Stroke study. METHODS: Baseline galectin-3 was measured in 455 cases of incident cognitive impairment and 546 controls. Galectin-3 was divide...

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Autores principales: Venkatraman, Anand, Callas, Peter, McClure, Leslie A., Unverzagt, Fred, Arora, Garima, Howard, Virginia, Wadley, Virginia G., Cushman, Mary, Arora, Pankaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944416/
https://www.ncbi.nlm.nih.gov/pubmed/29756004
http://dx.doi.org/10.1016/j.trci.2018.03.006
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author Venkatraman, Anand
Callas, Peter
McClure, Leslie A.
Unverzagt, Fred
Arora, Garima
Howard, Virginia
Wadley, Virginia G.
Cushman, Mary
Arora, Pankaj
author_facet Venkatraman, Anand
Callas, Peter
McClure, Leslie A.
Unverzagt, Fred
Arora, Garima
Howard, Virginia
Wadley, Virginia G.
Cushman, Mary
Arora, Pankaj
author_sort Venkatraman, Anand
collection PubMed
description INTRODUCTION: The relationship between serum galectin-3 and incident cognitive impairment was analyzed in the Reasons for Geographic and Racial Differences in Stroke study. METHODS: Baseline galectin-3 was measured in 455 cases of incident cognitive impairment and 546 controls. Galectin-3 was divided into quartiles based on the weighted distribution in the control group, and the first quartile was the referent. RESULTS: There was an increasing odds of cognitive impairment across quartiles of galectin-3 (odds ratios, 1.00 [0.68–1.46], 1.45 [1.01–2.10], and 1.58 [1.10–2.27] relative to the quartile 1; P trend = .003) in an unadjusted model, which persisted after adjusting for age, sex, and race (P = .004). Adjustment for cardiovascular risk factors greatly attenuated this association (odds ratios, 0.97 [0.60–1.57], 1.52 [0.94–2.46], and 1.27 [0.76–2.12]; P = .15). The association differed by diabetes status (P interaction, .007). Among nondiabetics (293 cases, 411 controls), those with galectin-3 in the fourth compared with first quartile had an odds ratio of 1.6 (0.95–2.99; P trend, .02). In diabetics, the odds ratio was 0.23 (0.04–1.33). DISCUSSION: Serum galectin-3 was associated with increased risk of incident cognitive impairment in a large cohort study of blacks and whites but only in nondiabetics.
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spelling pubmed-59444162018-05-11 Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites Venkatraman, Anand Callas, Peter McClure, Leslie A. Unverzagt, Fred Arora, Garima Howard, Virginia Wadley, Virginia G. Cushman, Mary Arora, Pankaj Alzheimers Dement (N Y) Featured Article INTRODUCTION: The relationship between serum galectin-3 and incident cognitive impairment was analyzed in the Reasons for Geographic and Racial Differences in Stroke study. METHODS: Baseline galectin-3 was measured in 455 cases of incident cognitive impairment and 546 controls. Galectin-3 was divided into quartiles based on the weighted distribution in the control group, and the first quartile was the referent. RESULTS: There was an increasing odds of cognitive impairment across quartiles of galectin-3 (odds ratios, 1.00 [0.68–1.46], 1.45 [1.01–2.10], and 1.58 [1.10–2.27] relative to the quartile 1; P trend = .003) in an unadjusted model, which persisted after adjusting for age, sex, and race (P = .004). Adjustment for cardiovascular risk factors greatly attenuated this association (odds ratios, 0.97 [0.60–1.57], 1.52 [0.94–2.46], and 1.27 [0.76–2.12]; P = .15). The association differed by diabetes status (P interaction, .007). Among nondiabetics (293 cases, 411 controls), those with galectin-3 in the fourth compared with first quartile had an odds ratio of 1.6 (0.95–2.99; P trend, .02). In diabetics, the odds ratio was 0.23 (0.04–1.33). DISCUSSION: Serum galectin-3 was associated with increased risk of incident cognitive impairment in a large cohort study of blacks and whites but only in nondiabetics. Elsevier 2018-04-26 /pmc/articles/PMC5944416/ /pubmed/29756004 http://dx.doi.org/10.1016/j.trci.2018.03.006 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Featured Article
Venkatraman, Anand
Callas, Peter
McClure, Leslie A.
Unverzagt, Fred
Arora, Garima
Howard, Virginia
Wadley, Virginia G.
Cushman, Mary
Arora, Pankaj
Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites
title Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites
title_full Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites
title_fullStr Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites
title_full_unstemmed Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites
title_short Galectin-3 and incident cognitive impairment in REGARDS, a cohort of blacks and whites
title_sort galectin-3 and incident cognitive impairment in regards, a cohort of blacks and whites
topic Featured Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944416/
https://www.ncbi.nlm.nih.gov/pubmed/29756004
http://dx.doi.org/10.1016/j.trci.2018.03.006
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