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Viromes of one year old infants reveal the impact of birth mode on microbiome diversity
Establishing a diverse gut microbiota after birth is being increasingly recognised as important for preventing illnesses later in life. It is well established that bacterial diversity rapidly increases post-partum; however, few studies have examined the infant gut virome/phageome during this develop...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944432/ https://www.ncbi.nlm.nih.gov/pubmed/29761040 http://dx.doi.org/10.7717/peerj.4694 |
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author | McCann, Angela Ryan, Feargal J. Stockdale, Stephen R. Dalmasso, Marion Blake, Tony Ryan, C. Anthony Stanton, Catherine Mills, Susan Ross, Paul R. Hill, Colin |
author_facet | McCann, Angela Ryan, Feargal J. Stockdale, Stephen R. Dalmasso, Marion Blake, Tony Ryan, C. Anthony Stanton, Catherine Mills, Susan Ross, Paul R. Hill, Colin |
author_sort | McCann, Angela |
collection | PubMed |
description | Establishing a diverse gut microbiota after birth is being increasingly recognised as important for preventing illnesses later in life. It is well established that bacterial diversity rapidly increases post-partum; however, few studies have examined the infant gut virome/phageome during this developmental period. We performed a metagenomic analysis of 20 infant faecal viromes at one year of age to determine whether spontaneous vaginal delivery (SVD) or caesarean section (CS) influenced viral composition. We find that birth mode results in distinctly different viral communities, with SVD infants having greater viral and bacteriophage diversity. We demonstrate that CrAssphage is acquired early in life, both in this cohort and two others, although no difference in birth mode is detected. A previous study has shown that bacterial OTU’s (operational taxonomic units) identified in the same infants could not discriminate between birth mode at 12 months of age. Therefore, our results indicate that vertical transmission of viral communities from mother to child may play a role in shaping the early life microbiome, and that birth mode should be considered when studying the early life gut virome. |
format | Online Article Text |
id | pubmed-5944432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59444322018-05-14 Viromes of one year old infants reveal the impact of birth mode on microbiome diversity McCann, Angela Ryan, Feargal J. Stockdale, Stephen R. Dalmasso, Marion Blake, Tony Ryan, C. Anthony Stanton, Catherine Mills, Susan Ross, Paul R. Hill, Colin PeerJ Microbiology Establishing a diverse gut microbiota after birth is being increasingly recognised as important for preventing illnesses later in life. It is well established that bacterial diversity rapidly increases post-partum; however, few studies have examined the infant gut virome/phageome during this developmental period. We performed a metagenomic analysis of 20 infant faecal viromes at one year of age to determine whether spontaneous vaginal delivery (SVD) or caesarean section (CS) influenced viral composition. We find that birth mode results in distinctly different viral communities, with SVD infants having greater viral and bacteriophage diversity. We demonstrate that CrAssphage is acquired early in life, both in this cohort and two others, although no difference in birth mode is detected. A previous study has shown that bacterial OTU’s (operational taxonomic units) identified in the same infants could not discriminate between birth mode at 12 months of age. Therefore, our results indicate that vertical transmission of viral communities from mother to child may play a role in shaping the early life microbiome, and that birth mode should be considered when studying the early life gut virome. PeerJ Inc. 2018-05-07 /pmc/articles/PMC5944432/ /pubmed/29761040 http://dx.doi.org/10.7717/peerj.4694 Text en ©2018 McCann et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Microbiology McCann, Angela Ryan, Feargal J. Stockdale, Stephen R. Dalmasso, Marion Blake, Tony Ryan, C. Anthony Stanton, Catherine Mills, Susan Ross, Paul R. Hill, Colin Viromes of one year old infants reveal the impact of birth mode on microbiome diversity |
title | Viromes of one year old infants reveal the impact of birth mode on microbiome diversity |
title_full | Viromes of one year old infants reveal the impact of birth mode on microbiome diversity |
title_fullStr | Viromes of one year old infants reveal the impact of birth mode on microbiome diversity |
title_full_unstemmed | Viromes of one year old infants reveal the impact of birth mode on microbiome diversity |
title_short | Viromes of one year old infants reveal the impact of birth mode on microbiome diversity |
title_sort | viromes of one year old infants reveal the impact of birth mode on microbiome diversity |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944432/ https://www.ncbi.nlm.nih.gov/pubmed/29761040 http://dx.doi.org/10.7717/peerj.4694 |
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