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Viromes of one year old infants reveal the impact of birth mode on microbiome diversity

Establishing a diverse gut microbiota after birth is being increasingly recognised as important for preventing illnesses later in life. It is well established that bacterial diversity rapidly increases post-partum; however, few studies have examined the infant gut virome/phageome during this develop...

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Autores principales: McCann, Angela, Ryan, Feargal J., Stockdale, Stephen R., Dalmasso, Marion, Blake, Tony, Ryan, C. Anthony, Stanton, Catherine, Mills, Susan, Ross, Paul R., Hill, Colin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944432/
https://www.ncbi.nlm.nih.gov/pubmed/29761040
http://dx.doi.org/10.7717/peerj.4694
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author McCann, Angela
Ryan, Feargal J.
Stockdale, Stephen R.
Dalmasso, Marion
Blake, Tony
Ryan, C. Anthony
Stanton, Catherine
Mills, Susan
Ross, Paul R.
Hill, Colin
author_facet McCann, Angela
Ryan, Feargal J.
Stockdale, Stephen R.
Dalmasso, Marion
Blake, Tony
Ryan, C. Anthony
Stanton, Catherine
Mills, Susan
Ross, Paul R.
Hill, Colin
author_sort McCann, Angela
collection PubMed
description Establishing a diverse gut microbiota after birth is being increasingly recognised as important for preventing illnesses later in life. It is well established that bacterial diversity rapidly increases post-partum; however, few studies have examined the infant gut virome/phageome during this developmental period. We performed a metagenomic analysis of 20 infant faecal viromes at one year of age to determine whether spontaneous vaginal delivery (SVD) or caesarean section (CS) influenced viral composition. We find that birth mode results in distinctly different viral communities, with SVD infants having greater viral and bacteriophage diversity. We demonstrate that CrAssphage is acquired early in life, both in this cohort and two others, although no difference in birth mode is detected. A previous study has shown that bacterial OTU’s (operational taxonomic units) identified in the same infants could not discriminate between birth mode at 12 months of age. Therefore, our results indicate that vertical transmission of viral communities from mother to child may play a role in shaping the early life microbiome, and that birth mode should be considered when studying the early life gut virome.
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spelling pubmed-59444322018-05-14 Viromes of one year old infants reveal the impact of birth mode on microbiome diversity McCann, Angela Ryan, Feargal J. Stockdale, Stephen R. Dalmasso, Marion Blake, Tony Ryan, C. Anthony Stanton, Catherine Mills, Susan Ross, Paul R. Hill, Colin PeerJ Microbiology Establishing a diverse gut microbiota after birth is being increasingly recognised as important for preventing illnesses later in life. It is well established that bacterial diversity rapidly increases post-partum; however, few studies have examined the infant gut virome/phageome during this developmental period. We performed a metagenomic analysis of 20 infant faecal viromes at one year of age to determine whether spontaneous vaginal delivery (SVD) or caesarean section (CS) influenced viral composition. We find that birth mode results in distinctly different viral communities, with SVD infants having greater viral and bacteriophage diversity. We demonstrate that CrAssphage is acquired early in life, both in this cohort and two others, although no difference in birth mode is detected. A previous study has shown that bacterial OTU’s (operational taxonomic units) identified in the same infants could not discriminate between birth mode at 12 months of age. Therefore, our results indicate that vertical transmission of viral communities from mother to child may play a role in shaping the early life microbiome, and that birth mode should be considered when studying the early life gut virome. PeerJ Inc. 2018-05-07 /pmc/articles/PMC5944432/ /pubmed/29761040 http://dx.doi.org/10.7717/peerj.4694 Text en ©2018 McCann et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Microbiology
McCann, Angela
Ryan, Feargal J.
Stockdale, Stephen R.
Dalmasso, Marion
Blake, Tony
Ryan, C. Anthony
Stanton, Catherine
Mills, Susan
Ross, Paul R.
Hill, Colin
Viromes of one year old infants reveal the impact of birth mode on microbiome diversity
title Viromes of one year old infants reveal the impact of birth mode on microbiome diversity
title_full Viromes of one year old infants reveal the impact of birth mode on microbiome diversity
title_fullStr Viromes of one year old infants reveal the impact of birth mode on microbiome diversity
title_full_unstemmed Viromes of one year old infants reveal the impact of birth mode on microbiome diversity
title_short Viromes of one year old infants reveal the impact of birth mode on microbiome diversity
title_sort viromes of one year old infants reveal the impact of birth mode on microbiome diversity
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944432/
https://www.ncbi.nlm.nih.gov/pubmed/29761040
http://dx.doi.org/10.7717/peerj.4694
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