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Flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections

Despite its benignity, upper respiratory infections (URIs) 1 increase the risk of postoperative respiratory complications during the perioperative and postoperative periods. Flumazenil could improve the symptoms of respiratory obstruction. To evaluate the effect of flumazenil on the occurrence of re...

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Autores principales: Sun, Ruiqiang, Wang, Guolin, Gao, Xuesong, Wang, Shuzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944528/
https://www.ncbi.nlm.nih.gov/pubmed/29703020
http://dx.doi.org/10.1097/MD.0000000000010516
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author Sun, Ruiqiang
Wang, Guolin
Gao, Xuesong
Wang, Shuzhen
author_facet Sun, Ruiqiang
Wang, Guolin
Gao, Xuesong
Wang, Shuzhen
author_sort Sun, Ruiqiang
collection PubMed
description Despite its benignity, upper respiratory infections (URIs) 1 increase the risk of postoperative respiratory complications during the perioperative and postoperative periods. Flumazenil could improve the symptoms of respiratory obstruction. To evaluate the effect of flumazenil on the occurrence of respiratory complications during anesthesia emergence of children with preoperative URI. This was a prospective study of 164 consecutive pediatric patients who underwent strabismus surgery under general anesthesia at the Tianjin Eye Hospital between August 2016 and April 2017. The patients were grouped as: normal airway (N), recent mild URI (I), normal airway and flumazenil (NF), and recent mild URI and flumazenil (group IF) (n = 41/group). An initial dose of flumazenil (0.1 mg) was administrated intravenously to groups IF and NF. The intraoperative and postoperative respiratory complications were recorded by one anesthesiologist unaware of the grouping. All patients underwent surgery uneventfully. The incidence of postoperative respiratory complications in post-anesthesia care unit (PACU) was higher in group I compared with the other 3 groups (IF: 17%; I: 41%; NF: 5%; N: 10%; P = .0147). During the PACU period, significant differences among groups were seen for cough (IF: 15%; I: 20%; NF: 2%; N: 0%; P = .004), secretion (IF: 17%; I: 29%; NF: 5%; N: 7%; P = .007), low oxygen saturation (IF: 12%; I: 32%; NF: 2%; N: 7%; P = .001), and glossocoma (IF: 15%; I: 34%; NF: 10%; N: 32%; P = .015). Respiratory complications during anesthesia emergence were higher in patients with recent preoperative URI compared to patients with healthy airways. Postoperative flumazenil could reduce the incidence of glossocoma.
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spelling pubmed-59445282018-05-15 Flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections Sun, Ruiqiang Wang, Guolin Gao, Xuesong Wang, Shuzhen Medicine (Baltimore) Research Article Despite its benignity, upper respiratory infections (URIs) 1 increase the risk of postoperative respiratory complications during the perioperative and postoperative periods. Flumazenil could improve the symptoms of respiratory obstruction. To evaluate the effect of flumazenil on the occurrence of respiratory complications during anesthesia emergence of children with preoperative URI. This was a prospective study of 164 consecutive pediatric patients who underwent strabismus surgery under general anesthesia at the Tianjin Eye Hospital between August 2016 and April 2017. The patients were grouped as: normal airway (N), recent mild URI (I), normal airway and flumazenil (NF), and recent mild URI and flumazenil (group IF) (n = 41/group). An initial dose of flumazenil (0.1 mg) was administrated intravenously to groups IF and NF. The intraoperative and postoperative respiratory complications were recorded by one anesthesiologist unaware of the grouping. All patients underwent surgery uneventfully. The incidence of postoperative respiratory complications in post-anesthesia care unit (PACU) was higher in group I compared with the other 3 groups (IF: 17%; I: 41%; NF: 5%; N: 10%; P = .0147). During the PACU period, significant differences among groups were seen for cough (IF: 15%; I: 20%; NF: 2%; N: 0%; P = .004), secretion (IF: 17%; I: 29%; NF: 5%; N: 7%; P = .007), low oxygen saturation (IF: 12%; I: 32%; NF: 2%; N: 7%; P = .001), and glossocoma (IF: 15%; I: 34%; NF: 10%; N: 32%; P = .015). Respiratory complications during anesthesia emergence were higher in patients with recent preoperative URI compared to patients with healthy airways. Postoperative flumazenil could reduce the incidence of glossocoma. Wolters Kluwer Health 2018-04-27 /pmc/articles/PMC5944528/ /pubmed/29703020 http://dx.doi.org/10.1097/MD.0000000000010516 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle Research Article
Sun, Ruiqiang
Wang, Guolin
Gao, Xuesong
Wang, Shuzhen
Flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections
title Flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections
title_full Flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections
title_fullStr Flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections
title_full_unstemmed Flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections
title_short Flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections
title_sort flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944528/
https://www.ncbi.nlm.nih.gov/pubmed/29703020
http://dx.doi.org/10.1097/MD.0000000000010516
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