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Frail and pre-frail phenotype is associated with pain in older HIV-infected patients

As HIV-infected patients grow older, some accumulate multiple health problems earlier than the noninfected ones in particular frailty phenotypes. Patients with frailty phenotype are at higher risk of adverse outcomes (worsening mobility, disability, hospitalization, and death within three years). Ou...

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Autores principales: Petit, Nathalie, Enel, Patricia, Ravaux, Isabelle, Darque, Albert, Baumstarck, Karine, Bregigeon, Sylvie, Retornaz, Frédérique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944687/
https://www.ncbi.nlm.nih.gov/pubmed/29419697
http://dx.doi.org/10.1097/MD.0000000000009852
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author Petit, Nathalie
Enel, Patricia
Ravaux, Isabelle
Darque, Albert
Baumstarck, Karine
Bregigeon, Sylvie
Retornaz, Frédérique
author_facet Petit, Nathalie
Enel, Patricia
Ravaux, Isabelle
Darque, Albert
Baumstarck, Karine
Bregigeon, Sylvie
Retornaz, Frédérique
author_sort Petit, Nathalie
collection PubMed
description As HIV-infected patients grow older, some accumulate multiple health problems earlier than the noninfected ones in particular frailty phenotypes. Patients with frailty phenotype are at higher risk of adverse outcomes (worsening mobility, disability, hospitalization, and death within three years). Our study aimed to evaluate prevalence of frailty in elderly HIV-infected patients and to assess whether frailty is associated with HIV and geriatric factors, comorbidities, and precariousness in a French cohort of older HIV infected. This 18-month cross-sectional multicenter study carried in 2013 to 2014 had involved 502 HIV-infected patients aged 50 years and older, cared in 18 HIV-dedicated hospital medical units, located in South of France. Prevalence of frailty was 6.3% and of pre-frailty 57.2%. Low physical activity and weakness were the main frailty markers, respectively 49.4% and 19.9%. In univariate models, precariousness, duration of HIV antiretroviral treatment >15 years, 2 comorbidities or more, risk of depression, activities of daily living disability, and presence of pain were significantly associated with frail and pre-frail phenotype. Multivariate logistic regression analyses showed that only pain was significantly different between frail and pre frail phenotype versus non frail phenotype (odds ratio = 1.2; P = .002). Our study is the first showing a significant association between pain and frailty phenotype in older patients infected by HIV. As frailty phenotype could be potentially reversible, a better understanding of the underlying determinant is warranted. Further studies are needed to confirm these first findings.
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spelling pubmed-59446872018-05-17 Frail and pre-frail phenotype is associated with pain in older HIV-infected patients Petit, Nathalie Enel, Patricia Ravaux, Isabelle Darque, Albert Baumstarck, Karine Bregigeon, Sylvie Retornaz, Frédérique Medicine (Baltimore) Research Article As HIV-infected patients grow older, some accumulate multiple health problems earlier than the noninfected ones in particular frailty phenotypes. Patients with frailty phenotype are at higher risk of adverse outcomes (worsening mobility, disability, hospitalization, and death within three years). Our study aimed to evaluate prevalence of frailty in elderly HIV-infected patients and to assess whether frailty is associated with HIV and geriatric factors, comorbidities, and precariousness in a French cohort of older HIV infected. This 18-month cross-sectional multicenter study carried in 2013 to 2014 had involved 502 HIV-infected patients aged 50 years and older, cared in 18 HIV-dedicated hospital medical units, located in South of France. Prevalence of frailty was 6.3% and of pre-frailty 57.2%. Low physical activity and weakness were the main frailty markers, respectively 49.4% and 19.9%. In univariate models, precariousness, duration of HIV antiretroviral treatment >15 years, 2 comorbidities or more, risk of depression, activities of daily living disability, and presence of pain were significantly associated with frail and pre-frail phenotype. Multivariate logistic regression analyses showed that only pain was significantly different between frail and pre frail phenotype versus non frail phenotype (odds ratio = 1.2; P = .002). Our study is the first showing a significant association between pain and frailty phenotype in older patients infected by HIV. As frailty phenotype could be potentially reversible, a better understanding of the underlying determinant is warranted. Further studies are needed to confirm these first findings. Wolters Kluwer Health 2018-02-09 /pmc/articles/PMC5944687/ /pubmed/29419697 http://dx.doi.org/10.1097/MD.0000000000009852 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Research Article
Petit, Nathalie
Enel, Patricia
Ravaux, Isabelle
Darque, Albert
Baumstarck, Karine
Bregigeon, Sylvie
Retornaz, Frédérique
Frail and pre-frail phenotype is associated with pain in older HIV-infected patients
title Frail and pre-frail phenotype is associated with pain in older HIV-infected patients
title_full Frail and pre-frail phenotype is associated with pain in older HIV-infected patients
title_fullStr Frail and pre-frail phenotype is associated with pain in older HIV-infected patients
title_full_unstemmed Frail and pre-frail phenotype is associated with pain in older HIV-infected patients
title_short Frail and pre-frail phenotype is associated with pain in older HIV-infected patients
title_sort frail and pre-frail phenotype is associated with pain in older hiv-infected patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944687/
https://www.ncbi.nlm.nih.gov/pubmed/29419697
http://dx.doi.org/10.1097/MD.0000000000009852
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