Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins

Inducing broad spectrum neutralizing antibodies against challenging pathogens such as HIV-1 is a major vaccine design goal, but may be hindered by conformational instability within viral envelope glycoproteins (Env). Chemical cross-linking is widely used for vaccine antigen stabilization, but how th...

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Detalles Bibliográficos
Autores principales: Schiffner, Torben, Pallesen, Jesper, Russell, Rebecca A., Dodd, Jonathan, de Val, Natalia, LaBranche, Celia C., Montefiori, David, Tomaras, Georgia D., Shen, Xiaoying, Harris, Scarlett L., Moghaddam, Amin E., Kalyuzhniy, Oleksandr, Sanders, Rogier W., McCoy, Laura E., Moore, John P., Ward, Andrew B., Sattentau, Quentin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944921/
https://www.ncbi.nlm.nih.gov/pubmed/29746590
http://dx.doi.org/10.1371/journal.ppat.1006986

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