Cargando…

Impact of the anatomical location, alcoholism and smoking on the prevalence of advanced oral cancer in Brazil

BACKGROUND: To evaluate the prevalence of oral cancer in Brazil according to the clinical stage, anatomical location, alcoholism and smoking. MATERIAL AND METHODS: Data referring to 31,217 cases of oral cancer, from 2000 to 2010, were obtained from the Integrator Module of the Hospital Registry of C...

Descripción completa

Detalles Bibliográficos
Autores principales: Bezerra, Natanael-Victor-Furtunato, Leite, Karla-Lorene-de França, de Medeiros, Mariana-Marinho-Davino, Martins, Mariana-Leonel, Cardoso, Andrea-Medeiros-Rodrigues, Alves, Pollianna-Muniz, Padilha, Wilton-Wilney-Nascimento, Cavalcanti, Yuri-Wanderley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945237/
https://www.ncbi.nlm.nih.gov/pubmed/29680854
http://dx.doi.org/10.4317/medoral.22318
_version_ 1783321962076962816
author Bezerra, Natanael-Victor-Furtunato
Leite, Karla-Lorene-de França
de Medeiros, Mariana-Marinho-Davino
Martins, Mariana-Leonel
Cardoso, Andrea-Medeiros-Rodrigues
Alves, Pollianna-Muniz
Padilha, Wilton-Wilney-Nascimento
Cavalcanti, Yuri-Wanderley
author_facet Bezerra, Natanael-Victor-Furtunato
Leite, Karla-Lorene-de França
de Medeiros, Mariana-Marinho-Davino
Martins, Mariana-Leonel
Cardoso, Andrea-Medeiros-Rodrigues
Alves, Pollianna-Muniz
Padilha, Wilton-Wilney-Nascimento
Cavalcanti, Yuri-Wanderley
author_sort Bezerra, Natanael-Victor-Furtunato
collection PubMed
description BACKGROUND: To evaluate the prevalence of oral cancer in Brazil according to the clinical stage, anatomical location, alcoholism and smoking. MATERIAL AND METHODS: Data referring to 31,217 cases of oral cancer, from 2000 to 2010, were obtained from the Integrator Module of the Hospital Registry of Cancer. Inconsistent data (“non-classified” cases) was eliminated and 21,160 cases were analyzed. The frequency distribution according to clinical stage, anatomical location, alcoholism and smoking was analyzed descriptively and through a binary logistic regression model (α<0.05). The clinical stage (dependent variable) was dichotomized in early stage (I and II) or advanced stage (III and IV). The year of diagnosis, anatomical location and deleterious habits (alcoholism and smoking) were considered independent variables. RESULTS: The most frequent characteristics were: oropharynx location (n=3856, 18.41%), clinical stage IV (n=11924, 56.09%) and combined use of alcohol and tobacco (n=19226; 61.59%). The year 2009 (p<0.01, PR = 1.162, CI-95%=1.053-1.283) and location at the base of tongue (p<0.01, PR = 2.485, CI-95% = 2.182-2.807) presented a higher prevalence ratio for advanced stage oral cancer. The combined use of alcohol and tobacco showed a higher prevalence rate for the advanced clinical stage of cancer (p<0.01, PR =1.449, CI-95%=1.382-1.520) if compared to individuals without habits, or just alcoholics. CONCLUSIONS: Higher prevalence of advanced stage of oral cancer is related to the localization at the base of the tongue and to the concomitant use of alcohol and tobacco. Therefore, it can be suggested that all these characteristics lead to a worse prognosis of oral cancer. Key words:Oral cancer, neoplasm staging, alcoholism, tobacco use disorder.
format Online
Article
Text
id pubmed-5945237
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Medicina Oral S.L.
record_format MEDLINE/PubMed
spelling pubmed-59452372018-05-15 Impact of the anatomical location, alcoholism and smoking on the prevalence of advanced oral cancer in Brazil Bezerra, Natanael-Victor-Furtunato Leite, Karla-Lorene-de França de Medeiros, Mariana-Marinho-Davino Martins, Mariana-Leonel Cardoso, Andrea-Medeiros-Rodrigues Alves, Pollianna-Muniz Padilha, Wilton-Wilney-Nascimento Cavalcanti, Yuri-Wanderley Med Oral Patol Oral Cir Bucal Research BACKGROUND: To evaluate the prevalence of oral cancer in Brazil according to the clinical stage, anatomical location, alcoholism and smoking. MATERIAL AND METHODS: Data referring to 31,217 cases of oral cancer, from 2000 to 2010, were obtained from the Integrator Module of the Hospital Registry of Cancer. Inconsistent data (“non-classified” cases) was eliminated and 21,160 cases were analyzed. The frequency distribution according to clinical stage, anatomical location, alcoholism and smoking was analyzed descriptively and through a binary logistic regression model (α<0.05). The clinical stage (dependent variable) was dichotomized in early stage (I and II) or advanced stage (III and IV). The year of diagnosis, anatomical location and deleterious habits (alcoholism and smoking) were considered independent variables. RESULTS: The most frequent characteristics were: oropharynx location (n=3856, 18.41%), clinical stage IV (n=11924, 56.09%) and combined use of alcohol and tobacco (n=19226; 61.59%). The year 2009 (p<0.01, PR = 1.162, CI-95%=1.053-1.283) and location at the base of tongue (p<0.01, PR = 2.485, CI-95% = 2.182-2.807) presented a higher prevalence ratio for advanced stage oral cancer. The combined use of alcohol and tobacco showed a higher prevalence rate for the advanced clinical stage of cancer (p<0.01, PR =1.449, CI-95%=1.382-1.520) if compared to individuals without habits, or just alcoholics. CONCLUSIONS: Higher prevalence of advanced stage of oral cancer is related to the localization at the base of the tongue and to the concomitant use of alcohol and tobacco. Therefore, it can be suggested that all these characteristics lead to a worse prognosis of oral cancer. Key words:Oral cancer, neoplasm staging, alcoholism, tobacco use disorder. Medicina Oral S.L. 2018-05 2018-04-24 /pmc/articles/PMC5945237/ /pubmed/29680854 http://dx.doi.org/10.4317/medoral.22318 Text en Copyright: © 2018 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Bezerra, Natanael-Victor-Furtunato
Leite, Karla-Lorene-de França
de Medeiros, Mariana-Marinho-Davino
Martins, Mariana-Leonel
Cardoso, Andrea-Medeiros-Rodrigues
Alves, Pollianna-Muniz
Padilha, Wilton-Wilney-Nascimento
Cavalcanti, Yuri-Wanderley
Impact of the anatomical location, alcoholism and smoking on the prevalence of advanced oral cancer in Brazil
title Impact of the anatomical location, alcoholism and smoking on the prevalence of advanced oral cancer in Brazil
title_full Impact of the anatomical location, alcoholism and smoking on the prevalence of advanced oral cancer in Brazil
title_fullStr Impact of the anatomical location, alcoholism and smoking on the prevalence of advanced oral cancer in Brazil
title_full_unstemmed Impact of the anatomical location, alcoholism and smoking on the prevalence of advanced oral cancer in Brazil
title_short Impact of the anatomical location, alcoholism and smoking on the prevalence of advanced oral cancer in Brazil
title_sort impact of the anatomical location, alcoholism and smoking on the prevalence of advanced oral cancer in brazil
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945237/
https://www.ncbi.nlm.nih.gov/pubmed/29680854
http://dx.doi.org/10.4317/medoral.22318
work_keys_str_mv AT bezerranatanaelvictorfurtunato impactoftheanatomicallocationalcoholismandsmokingontheprevalenceofadvancedoralcancerinbrazil
AT leitekarlalorenedefranca impactoftheanatomicallocationalcoholismandsmokingontheprevalenceofadvancedoralcancerinbrazil
AT demedeirosmarianamarinhodavino impactoftheanatomicallocationalcoholismandsmokingontheprevalenceofadvancedoralcancerinbrazil
AT martinsmarianaleonel impactoftheanatomicallocationalcoholismandsmokingontheprevalenceofadvancedoralcancerinbrazil
AT cardosoandreamedeirosrodrigues impactoftheanatomicallocationalcoholismandsmokingontheprevalenceofadvancedoralcancerinbrazil
AT alvespolliannamuniz impactoftheanatomicallocationalcoholismandsmokingontheprevalenceofadvancedoralcancerinbrazil
AT padilhawiltonwilneynascimento impactoftheanatomicallocationalcoholismandsmokingontheprevalenceofadvancedoralcancerinbrazil
AT cavalcantiyuriwanderley impactoftheanatomicallocationalcoholismandsmokingontheprevalenceofadvancedoralcancerinbrazil