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Liver Fluke-Associated Biliary Tract Cancer

Cholangiocarcinoma (CCA) is an aggressive cancer arising from epithelial cells of the bile duct. Most patients with CCA have an unresectable tumor at the time of diagnosis. In Western countries, the risk of CCA increases in patients with primary sclerosing cholangitis, whereas liver fluke infection...

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Autores principales: Prueksapanich, Piyapan, Piyachaturawat, Panida, Aumpansub, Prapimphan, Ridtitid, Wiriyaporn, Chaiteerakij, Roongruedee, Rerknimitr, Rungsun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of Gut and Liver 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945254/
https://www.ncbi.nlm.nih.gov/pubmed/28783896
http://dx.doi.org/10.5009/gnl17102
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author Prueksapanich, Piyapan
Piyachaturawat, Panida
Aumpansub, Prapimphan
Ridtitid, Wiriyaporn
Chaiteerakij, Roongruedee
Rerknimitr, Rungsun
author_facet Prueksapanich, Piyapan
Piyachaturawat, Panida
Aumpansub, Prapimphan
Ridtitid, Wiriyaporn
Chaiteerakij, Roongruedee
Rerknimitr, Rungsun
author_sort Prueksapanich, Piyapan
collection PubMed
description Cholangiocarcinoma (CCA) is an aggressive cancer arising from epithelial cells of the bile duct. Most patients with CCA have an unresectable tumor at the time of diagnosis. In Western countries, the risk of CCA increases in patients with primary sclerosing cholangitis, whereas liver fluke infection appears to be the major risk factor for CCA in Asian countries. A diagnosis of liver fluke infection often relies on stool samples, including microscopic examination, polymerase chain reaction-based assays, and fluke antigen detection. Tests of serum, saliva and urine samples are also potentially diagnostic. The presence of liver fluke along with exogenous carcinogens magnifies the risk of CCA in people living in endemic areas. The “liver fluke-cholangiocarcinoma” carcinogenesis pathways consist of mechanical damage to the bile duct epithelium, immunopathologic and cellular reactions to the liver fluke’s antigens and excretory/secretory products, liver fluke-induced changes in the biliary tract microbiome and the effects of repeated treatment for liver fluke. A vaccine and novel biomarkers are needed for the primary and secondary prevention of CCA in endemic areas. Importantly, climate change exerts an effect on vector-borne parasitic diseases, and awareness of liver fluke should be enhanced in potentially migrated habitat areas.
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spelling pubmed-59452542018-05-16 Liver Fluke-Associated Biliary Tract Cancer Prueksapanich, Piyapan Piyachaturawat, Panida Aumpansub, Prapimphan Ridtitid, Wiriyaporn Chaiteerakij, Roongruedee Rerknimitr, Rungsun Gut Liver Review Cholangiocarcinoma (CCA) is an aggressive cancer arising from epithelial cells of the bile duct. Most patients with CCA have an unresectable tumor at the time of diagnosis. In Western countries, the risk of CCA increases in patients with primary sclerosing cholangitis, whereas liver fluke infection appears to be the major risk factor for CCA in Asian countries. A diagnosis of liver fluke infection often relies on stool samples, including microscopic examination, polymerase chain reaction-based assays, and fluke antigen detection. Tests of serum, saliva and urine samples are also potentially diagnostic. The presence of liver fluke along with exogenous carcinogens magnifies the risk of CCA in people living in endemic areas. The “liver fluke-cholangiocarcinoma” carcinogenesis pathways consist of mechanical damage to the bile duct epithelium, immunopathologic and cellular reactions to the liver fluke’s antigens and excretory/secretory products, liver fluke-induced changes in the biliary tract microbiome and the effects of repeated treatment for liver fluke. A vaccine and novel biomarkers are needed for the primary and secondary prevention of CCA in endemic areas. Importantly, climate change exerts an effect on vector-borne parasitic diseases, and awareness of liver fluke should be enhanced in potentially migrated habitat areas. Editorial Office of Gut and Liver 2018-05 2017-08-09 /pmc/articles/PMC5945254/ /pubmed/28783896 http://dx.doi.org/10.5009/gnl17102 Text en Copyright © 2018 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Prueksapanich, Piyapan
Piyachaturawat, Panida
Aumpansub, Prapimphan
Ridtitid, Wiriyaporn
Chaiteerakij, Roongruedee
Rerknimitr, Rungsun
Liver Fluke-Associated Biliary Tract Cancer
title Liver Fluke-Associated Biliary Tract Cancer
title_full Liver Fluke-Associated Biliary Tract Cancer
title_fullStr Liver Fluke-Associated Biliary Tract Cancer
title_full_unstemmed Liver Fluke-Associated Biliary Tract Cancer
title_short Liver Fluke-Associated Biliary Tract Cancer
title_sort liver fluke-associated biliary tract cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945254/
https://www.ncbi.nlm.nih.gov/pubmed/28783896
http://dx.doi.org/10.5009/gnl17102
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