Inhibition of mTOR complex 2 restrains tumor angiogenesis in multiple myeloma

The mammalian Target of Rapamycin (mTOR) is an intracellular serine/threonine kinase that mediates intracellular metabolism, cell survival and actin rearrangement. mTOR is made of two independent complexes, mTORC1 and mTORC2, activated by the scaffold proteins RAPTOR and RICTOR, respectively. The ac...

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Detalles Bibliográficos
Autores principales: Lamanuzzi, Aurelia, Saltarella, Ilaria, Desantis, Vanessa, Frassanito, Maria Antonia, Leone, Patrizia, Racanelli, Vito, Nico, Beatrice, Ribatti, Domenico, Ditonno, Paolo, Prete, Marcella, Solimando, Antonio Giovanni, Dammacco, Francesco, Vacca, Angelo, Ria, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945497/
https://www.ncbi.nlm.nih.gov/pubmed/29755672
http://dx.doi.org/10.18632/oncotarget.25003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945497/
https://www.ncbi.nlm.nih.gov/pubmed/29755672
http://dx.doi.org/10.18632/oncotarget.25003

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