TumorNext-Lynch-MMR: a comprehensive next generation sequencing assay for the detection of germline and somatic mutations in genes associated with mismatch repair deficiency and Lynch syndrome

The current algorithm for Lynch syndrome diagnosis is highly complex with multiple steps which can result in an extended time to diagnosis while depleting precious tumor specimens. Here we describe the analytical validation of a custom probe-based NGS tumor panel, TumorNext-Lynch-MMR, which generate...

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Detalles Bibliográficos
Autores principales: Gray, Phillip N., Tsai, Pei, Chen, Daniel, Wu, Sitao, Hoo, Jayne, Mu, Wenbo, Li, Bing, Vuong, Huy, Lu, Hsiao-Mei, Batth, Navanjot, Willett, Sara, Uyeda, Lisa, Shah, Swati, Gau, Chia-Ling, Umali, Monalyn, Espenschied, Carin, Janicek, Mike, Brown, Sandra, Margileth, David, Dobrea, Lavinia, Wagman, Lawrence, Rana, Huma, Hall, Michael J., Ross, Theodora, Terdiman, Jonathan, Cullinane, Carey, Ries, Savita, Totten, Ellen, Elliott, Aaron M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945525/
https://www.ncbi.nlm.nih.gov/pubmed/29755653
http://dx.doi.org/10.18632/oncotarget.24854

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