Coffee consumption is not associated with ovarian cancer risk: a dose-response meta-analysis of prospective cohort studies

BACKGROUND: Coffee consumption has been associated with numerous cancers, but evidence on ovarian cancer risk is controversial. Therefore, we performed a meta-analysis on prospective cohort studies in order to review the evidence on coffee consumption and risk of ovarian cancer. METHODS: Studies wer...

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Detalles Bibliográficos
Autores principales: Berretta, Massimiliano, Micek, Agnieszka, Lafranconi, Alessandra, Rossetti, Sabrina, Di Francia, Raffaele, De Paoli, Paolo, Rossi, Paola, Facchini, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Meta-Analysis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945528/
https://www.ncbi.nlm.nih.gov/pubmed/29755691
http://dx.doi.org/10.18632/oncotarget.24829
Descripción
Sumario:BACKGROUND: Coffee consumption has been associated with numerous cancers, but evidence on ovarian cancer risk is controversial. Therefore, we performed a meta-analysis on prospective cohort studies in order to review the evidence on coffee consumption and risk of ovarian cancer. METHODS: Studies were identified through searching the PubMed and MEDLINE databases up to March 2017. Risk estimates were retrieved from the studies, and dose-response analysis was modelled by using restricted cubic splines. Additionally, a stratified analysis by menopausal status was performed. RESULTS: A total of 8 studies were eligible for the dose-response meta-analysis. Studies included in the analysis comprised 787,076 participants and 3,541 ovarian cancer cases. The results showed that coffee intake was not associated with ovarian cancer risk (RR = 1.06, 95% CI: 0.89, 1.26). Stratified and subgroup analysis showed consisted results. CONCLUSIONS: This comprehensive meta-analysis did not find evidence of an association between the consumption of coffee and risk of ovarian cancer.

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